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Cellosaurus KMS-21-BM (CVCL_2991)

Cell line name KMS-21-BM
Synonyms KMS-21BM; KMS21BM
Accession CVCL_2991
Resource Identification Initiative To cite this cell line use: KMS-21-BM (RRID:CVCL_2991)
Comments Problematic cell line: Misidentified. Originally thought to be a myeloma cell line and to be a sister line to KMS-21-PE (CVCL_A445) but this does not seem to be the case (PubMed=12592342; PubMed=20143388).
Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00228.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Undefined cell line type
STR profile Source(s): JCRB; PubMed=25877200

Markers:
AmelogeninX
CSF1PO12,13
D13S3178,14
D16S5399
D18S5113
D21S1131,32.2
D3S135815,17
D5S81810,11
D7S8208,13
D8S117912
FGA19,22,23
Penta D9,10
Penta E11,12
TH017,9
TPOX8
vWA18
Web pages http://iclac.org/wp-content/uploads/Cross-Contaminations_v9_distribution.xlsx
Publications

DOI=10.1002/1438-826X(200005)1:1<48::AID-GNFD48>3.0.CO;2-B
Otsuki T., Yamada O., Yata K., Nakazawa N., Taniwaki M., Sakaguchi H., Yawata Y., Ueki A.
Genetic and biological characterization of human myeloma cell lines: an overview of the lines established at Kawasaki Medical School.
Gene Funct. Dis. 1:48-56(2000)

PubMed=11697507; DOI=10.3109/10428190109099339
Otsuki T., Wada H., Nakazawa N., Taniwaki M., Kouguchi K., Ohkura M., Uehira K., Isoda K., Yata K., Sakaguchi H., Yawata Y., Ueki A., Yamada O.
Establishment of CD7+ human myeloma sister cell lines, KMS-21-PE and KMS-21-BM, carrying t(11;14) and t(8;14).
Leuk. Lymphoma 42:761-774(2001)

PubMed=12592342; DOI=10.1038/sj.leu.2402799
Drexler H.G., Dirks W.G., Matsuo Y., MacLeod R.A.F.
False leukemia-lymphoma cell lines: an update on over 500 cell lines.
Leukemia 17:416-426(2003)

PubMed=15215163; DOI=10.1016/S0002-9440(10)63276-2
Inoue J., Otsuki T., Hirasawa A., Imoto I., Matsuo Y., Shimizu S., Taniwaki M., Inazawa J.
Overexpression of PDZK1 within the 1q12-q22 amplicon is likely to be associated with drug-resistance phenotype in multiple myeloma.
Am. J. Pathol. 165:71-81(2004)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

Cross-references
Cell line collections JCRB; JCRB1185
JCRB; NIHS0485 - Discontinued
Cell line databases/resources CCLE; KMS21BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
CGH-DB; 30-1
CGH-DB; 9143-4
Ontologies EFO; EFO_0006614
Biological sample resources BioSample; SAMN03152019
BioSample; SAMN03472923
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
GEO; GSM887224
GEO; GSM888298
Other Wikidata; Q54900172