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Cellosaurus KMS-28PE (CVCL_2995)

[Text version]

Cell line name KMS-28PE
Synonyms KMS-28-PE; KMS28PE; Kawasaki Medical School-28-Pleural Effusion
Accession CVCL_2995
Resource Identification Initiative To cite this cell line use: KMS-28PE (RRID:CVCL_2995)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Japanese.
Omics: Array-based CGH.
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Derived from sampling site: Pleural effusion.
Sequence variations
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Ala (c.35G>C); ClinVar=VCV000045122; Zygosity=Homozygous (DepMap).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gly105Arg (c.313G>C); ClinVar=VCV000406574; Zygosity=Homozygous (DepMap).
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_2994 ! KMS-28BM
Sex of cell Female
Age at sampling 77Y
Category Cancer cell line
STR profile Source(s): DepMap; JCRB

Markers:
AmelogeninX
CSF1PO10
D3S135816
D5S81814
D7S8208,11
D8S117910,11
D13S31711
D16S5399,11
D18S5114,15
D21S1130
FGA20,23
Penta D9,11
Penta E12,15
TH017,9.3
TPOX8,9
vWA17

Run an STR similarity search on this cell line
Web pages https://www.keatslab.org/myeloma-cell-lines/hmcl-characteristics
Publications

PubMed=15215163; DOI=10.1016/S0002-9440(10)63276-2
Inoue J., Otsuki T., Hirasawa A., Imoto I., Matsuo Y., Shimizu S., Taniwaki M., Inazawa J.
Overexpression of PDZK1 within the 1q12-q22 amplicon is likely to be associated with drug-resistance phenotype in multiple myeloma.
Am. J. Pathol. 165:71-81(2004)

PubMed=17692805; DOI=10.1016/j.ccr.2007.07.003
Keats J.J., Fonseca R., Chesi M., Schop R., Baker A., Chng W.-J., Van Wier S., Tiedemann R., Shi C.-X., Sebag M., Braggio E., Henry T., Zhu Y.-X., Fogle H., Price-Troska T.L., Ahmann G.J., Mancini C., Brents L.A., Kumar S., Greipp P., Dispenzieri A., Bryant B., Mulligan G., Bruhn L., Barrett M.T., Valdez R., Trent J.M., Stewart A.K., Carpten J., Bergsagel P.L.
Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma.
Cancer Cell 12:131-144(2007)

PubMed=18647998; DOI=10.1093/jncimonographs/lgn011
Dib A., Gabrea A., Glebov O.K., Bergsagel P.L., Kuehl W.M.
Characterization of MYC translocations in multiple myeloma cell lines.
J. Natl. Cancer Inst. Monogr. 39:25-31(2008)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

CLPUB00604
Chow S.
Targeted capture and sequencing of immunoglobulin rearrangements in multiple myeloma to enable detection of minimal residual disease.
Thesis MSc (2017), University of Toronto, Canada

Cross-references
Cell line collections JCRB; JCRB1191
JCRB; NIHS0489 - Discontinued
Cell line databases/resources CGH-DB; 33-1
CGH-DB; 9144-4
Cell_Model_Passport; SIDM01656
Cell_Model_Passport; SIDM01797
DepMap; ACH-001541
Lonza; 1429
Chemistry resources PharmacoDB; KMS28PE_771_2019
Encyclopedic resources Wikidata; Q54900178
Experimental variables resources EFO; EFO_0006618
Gene expression databases ArrayExpress; E-MTAB-2706
GEO; GSM621589
Polymorphism and mutation databases Cosmic; 2081428
Cosmic; 2081440
Cosmic; 2367289
Progenetix; CVCL_2995
Sequence databases EGA; EGAS00001002554
Entry history
Entry creation04-Apr-2012
Last entry update17-Mar-2022
Version number25