Cellosaurus cell line KMST-6 (CVCL_2998)

• Mutation; HGNC; 11998; TP53; Simple; p.His179Pro (c.536A>C); ClinVar=VCV000376611; Zygosity=Heterozygous (PubMed=8790940).
  

PubMed=3972471; DOI=10.1002/ijc.2910350221
Namba M., Nishitani K., Hyodoh F., Fukushima F., Kimoto T.
Neoplastic transformation of human diploid fibroblasts (KMST-6) by treatment with 60Co gamma rays.
Int. J. Cancer 35:275-280(1985)

PubMed=2423124; DOI=10.1016/0304-419X(86)90001-6
Chang S.E.
In vitro transformation of human epithelial cells.
Biochim. Biophys. Acta 823:161-194(1986)

PubMed=3140712
Namba M., Nishitani K., Fukushima F., Kimoto T.
Multistep carcinogenesis of normal human fibroblasts. Human fibroblasts immortalized by repeated treatment with Co-60 gamma rays were transformed into tumorigenic cells with Ha-ras oncogenes.
Anticancer Res. 8:947-958(1988)

PubMed=1537630; DOI=10.1002/ijc.2910500426
Mihara K., Bai L., Kano Y., Miyazaki M., Namba M.
Malignant transformation of human fibroblasts previously immortalized with 60Co gamma rays.
Int. J. Cancer 50:639-643(1992)

DOI=10.11418/jtca1981.12.4_313
Namba M., Bai L., Kano Y., Sugihara S., Miyazaki M.
Multistep malignant transformation of human cells: immortalization of human fibroblasts by treatment with 60Co gamma rays and 4-nitroquinoline 1-oxide, and their malignant transformation with the ras oncogene.
Tissue Cult. Res. Commun. 12:313-318(1993)

PubMed=8105370; DOI=10.1128/mcb.13.10.6036-6043.1993
Ogata T., Ayusawa D., Namba M., Takahashi E., Oshimura M., Oishi M.
Chromosome 7 suppresses indefinite division of nontumorigenic immortalized human fibroblast cell lines KMST-6 and SUSM-1.
Mol. Cell. Biol. 13:6036-6043(1993)

PubMed=8148305
Namba M., Iijima M., Kondo T., Jahan I., Mihara K.
Immortalization of normal human cells is a multistep process and a rate limiting step of neoplastic transformation of the cells.
Hum. Cell 6:253-259(1993)

PubMed=8557247; DOI=10.1007/BF00218823
Sugihara S., Mihara K., Marunouchi T., Inoue H., Namba M.
Telomere elongation observed in immortalized human fibroblasts by treatment with 60Co gamma rays or 4-nitroquinoline 1-oxide.
Hum. Genet. 97:1-6(1996)

PubMed=8790940; DOI=10.1247/csf.21.111
Mihara K., Iijima M., Kondo T., Namba M.
Selective expression of mutated p53 in human cells immortalized with either 4-nitroquinoline 1-oxide or 60Co gamma rays.
Cell Struct. Funct. 21:111-116(1996)

DOI=10.11418/jtca1981.16.3_173
Mihara K., Miyazaki M., Fushimi K., Tsuji T., Inoue Y., Fukaya K.-i., Ohashi R., Namba M.
The p53 gene status and other cellular characteristics of human cell lines maintained in our laboratory.
Tissue Cult. Res. Commun. 16:173-178(1997)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=9359923; DOI=10.18926/AMO/30789
Mihara K., Miyazaki M., Kondo T., Fushimi K., Tsuji T., Inoue Y., Fukaya K.-i., Ishioka C., Namba M.
Yeast functional assay of the p53 gene status in human cell lines maintained in our laboratory.
Acta Med. Okayama 51:261-265(1997)

CLPUB00712
Henson J.D.
The role of alternative lengthening of telomeres in human cancer.
Thesis PhD (2006), University of Sydney, Australia

PubMed=19935656; DOI=10.1038/nbt.1587
Henson J.D., Cao Y., Huschtscha L.I., Chang A.C.-M., Au A.Y.M., Pickett H.A., Reddel R.R.
DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity.
Nat. Biotechnol. 27:1181-1185(2009)