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Cellosaurus DT40-PTPN6(-/-) (CVCL_2G91)

[Text version]
Cell line name DT40-PTPN6(-/-)
Synonyms SHP1^(-) DT40; SHP-1-deficient DT40
Accession CVCL_2G91
Resource Identification Initiative To cite this cell line use: DT40-PTPN6(-/-) (RRID:CVCL_2G91)
Comments Group: Bird cell line.
Knockout cell: Method=Targeted integration; UniProtKB; F1N843; PTPN6.
Transformant: NCBI_TaxID; 11864; Avian leukosis virus (ALV).
Cell type: B-cell; CL=CL_0000236.
Disease Chicken bursal lymphoma (NCIt: C134556)
Species of origin Gallus gallus (Chicken) (NCBI Taxonomy: 9031)
Breed/subspecies: Hy-Line SC.
Hierarchy Parent: CVCL_0249 (DT40)
Children:
CVCL_2G92 (DT40-PTPN6(-/-)-PTPN11(-/-))
Sex of cell Female
Age at sampling 1D
Category Cancer cell line
Publications

PubMed=9244303; DOI=10.1016/S0092-8674(00)80337-2
Ono M., Okada H., Bolland S., Yanagi S., Kurosaki T., Ravetch J.V.
Deletion of SHIP or SHP-1 reveals two distinct pathways for inhibitory signaling.
Cell 90:293-301(1997)

PubMed=9547347; DOI=10.1084/jem.187.8.1355
Maeda A., Kurosaki M., Ono M., Takai T., Kurosaki T.
Requirement of SH2-containing protein tyrosine phosphatases SHP-1 and SHP-2 for paired immunoglobulin-like receptor B (PIR-B)-mediated inhibitory signal.
J. Exp. Med. 187:1355-1360(1998)

Cross-references
Cell line collections (Providers) RCB; RCB1466
Cell line databases/resources CLO; CLO_0051460
Encyclopedic resources Wikidata; Q54831510
Entry history
Entry creation22-Sep-2015
Last entry update30-Jan-2024
Version number10