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Cellosaurus KO51 (CVCL_3000)

Cell line name KO51
Synonyms K051; K-051
Accession CVCL_3000
Secondary accession CVCL_8454
Resource Identification Initiative To cite this cell line use: KO51 (RRID:CVCL_3000)
Comments Problematic cell line: Contaminated. Shown to be a K-562 derivative (PubMed=12592342; PubMed=20143388). Originally thought to originate from the bone marrow of 46 year old male patient suffering from acute myeloid leukemia.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00217.
Derived from sampling site: Pleural effusion.
Sequence variations Homozygous for TP53 p.Gln136fs*13 (c.406_407insC) (from parent cell line).
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
STR profile Source(s): JCRB

Markers:
AmelogeninX
CSF1PO9,10
D13S3178
D16S53911,12
D5S81811,12
D7S8209,11
TH019.3
TPOX8,9
vWA16
Web pages http://iclac.org/wp-content/uploads/Cross-Contaminations_v9_distribution.xlsx
Publications

PubMed=7693050
Abo J., Inokuchi K., Dan K., Nomura T.
p53 and N-ras mutations in two new leukemia cell lines established from a patient with multilineage CD7-positive acute leukemia.
Blood 82:2829-2836(1993)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=12592342; DOI=10.1038/sj.leu.2402799
Drexler H.G., Dirks W.G., Matsuo Y., MacLeod R.A.F.
False leukemia-lymphoma cell lines: an update on over 500 cell lines.
Leukemia 17:416-426(2003)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cross-references
Cell line collections JCRB; JCRB0122
JCRB; NIHS0163 - Discontinued
JCRB; NIHS0244 - Discontinued
Biological sample resources BioSample; SAMN03151809
Other Wikidata; Q54900261
Polymorphism and mutation databases Cosmic; 749072
Cosmic; 787440
Cosmic; 975257
Cosmic; 1281320