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Cellosaurus KON (CVCL_3001)

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Cell line name KON
Accession CVCL_3001
Resource Identification Initiative To cite this cell line use: KON (RRID:CVCL_3001)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: 32.5 hours, at 28th passage (DOI=10.5794/jjoms.41.19), 43 hours (lot 01262007) (JCRB).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Misspelling: KOS; In CGH-DB 369-2.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.36
Native American0.46
East Asian, North79.36
East Asian, South18.6
South Asian0.7
European, North0.27
European, South0.25
Disease Floor of mouth squamous cell carcinoma (NCIt: C4041)
Derived from metastatic site: Cervical lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 76Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB

Markers:
AmelogeninX
CSF1PO11,12
D5S81811,13
D7S8208,11
D13S31711,12
D16S5399,11
TH017,9
TPOX9,11
vWA17 (Cosmic-CLP)
16,17 (JCRB)

Run an STR similarity search on this cell line
Publications

DOI=10.5794/jjoms.41.19
Ohara M., Yasui A., Ishikawa T.
Establishment and characterization of a human oral squamous cell carcinoma cell line (KON).
Nihon Koku Geka Gakkai Zasshi 41:19-25(1995)

PubMed=17599052; DOI=10.1038/sj.onc.1210589
Suzuki E., Imoto I., Pimkhaokham A., Nakagawa T., Kamata N., Kozaki K.-I., Amagasa T., Inazawa J.
PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation.
Oncogene 26:7921-7932(2007)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections JCRB; JCRB0194
Cell line databases/resources CGH-DB; 369-2
CCLE; KON_UPPER_AERODIGESTIVE_TRACT
Cell_Model_Passport; SIDM00604
Cosmic-CLP; 1298215
DepMap; ACH-001542
GDSC; 1298215
LINCS_LDP; LCL-1207
Biological sample resources BioSample; SAMN03471653
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM827191
GEO; GSM1669999
Other Wikidata; Q54900289
Polymorphism and mutation databases Cosmic; 1995473
Entry history
Entry creation04-Apr-2012
Last entry updated05-Jul-2019
Version number22