Cellosaurus KP-1N (CVCL_3002)

Cell line name KP-1N
Synonyms Kp-1N; KP-1 N; KP1N; KP1
Accession CVCL_3002
Resource Identification Initiative To cite this cell line use: KP-1N (RRID:CVCL_3002)
Comments Problematic cell line: Contaminated. Shown to be a PANC-1 derivative.
Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Microsatellite instability: Stable (MSS) (Sanger).
Sequence variation: Homozygous for a CDKN2A deletion (from parent cell line).
Sequence variation: Heterozygous for KRAS p.Gly12Asp (from parent cell line).
Sequence variation: TP53 p.Arg273His (from parent cell line).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Disease Pancreatic ductal adenocarcinoma (NCIt: C9120)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0480 (PANC-1)
CVCL_3003 (KP-1NL)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB

Web pages http://iclac.org/wp-content/uploads/Cross-Contaminations-v8_0.pdf

PubMed=2172194; DOI=10.1111/j.1349-7006.1990.tb03336.x
Ikeda Y., Ezaki M., Hayashi I., Yasuda D., Nakayama K., Kono A.
Establishment and characterization of human pancreatic cancer cell lines in tissue culture and in nude mice.
Jpn. J. Cancer Res. 81:987-993(1990)

PubMed=18380791; DOI=10.1111/j.1349-7006.2008.00779.x
Suzuki A., Shibata T., Shimada Y., Murakami Y., Horii A., Shiratori K., Hirohashi S., Inazawa J., Imoto I.
Identification of SMURF1 as a possible target for 7q21.3-22.1 amplification detected in a pancreatic cancer cell line by in-house array-based comparative genomic hybridization.
Cancer Sci. 99:986-994(2008)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cell line collections JCRB; JCRB0177.0
JCRB; NIHS0274.0 - Discontinued
Cell line databases/resources CCLE; KP1N_PANCREAS
CGH-DB; 173-1
CGH-DB; 9368-4
Cosmic-CLP; 1298216
GDSC; 1298216
Ontologies BTO; BTO:0003549
Biological sample resources BioSample; SAMN03151887
Gene expression databases GEO; GSM827208
GEO; GSM1670002
Polymorphism and mutation databases Cosmic; 918052
Cosmic; 1122345
Cosmic; 1518234
Cosmic; 1995474