Cellosaurus KP-1NL (CVCL_3003)

Cell line name KP-1NL
Synonyms KP-1N-L; KP-1-NL; KP1-NL; KP1NL
Accession CVCL_3003
Resource Identification Initiative To cite this cell line use: KP-1NL (RRID:CVCL_3003)
Comments Problematic cell line: Contaminated. Parent cell line (KP-1N) has been shown to be a PANC-1 derivative.
Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: 25 hours (PubMed=25984343).
Sequence variation: KRAS p.Gly12Asp (from parent cell line).
Sequence variation: TP53 p.Arg273His (from parent cell line).
Sequence variation: Homozygous for a CDKN2A deletion (from parent cell line).
Omics: shRNA library screening.
Disease Pancreatic ductal adenocarcinoma (NCIt: C9120)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_3002 (KP-1N)
Children: CVCL_4Y21 (KP-1NL-Luc#2)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): JCRB

Markers:
AmelogeninX
CSF1PO10,12
D13S31711
D16S53911
D5S81811,13
D7S8208,10
TH017,8
TPOX8,11
vWA15
Publications

PubMed=2172194; DOI=10.1111/j.1349-7006.1990.tb03336.x
Ikeda Y., Ezaki M., Hayashi I., Yasuda D., Nakayama K., Kono A.
Establishment and characterization of human pancreatic cancer cell lines in tissue culture and in nude mice.
Jpn. J. Cancer Res. 81:987-993(1990)

PubMed=18380791; DOI=10.1111/j.1349-7006.2008.00779.x
Suzuki A., Shibata T., Shimada Y., Murakami Y., Horii A., Shiratori K., Hirohashi S., Inazawa J., Imoto I.
Identification of SMURF1 as a possible target for 7q21.3-22.1 amplification detected in a pancreatic cancer cell line by in-house array-based comparative genomic hybridization.
Cancer Sci. 99:986-994(2008)

PubMed=25984343; DOI=10.1038/sdata.2014.35
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Hill Meyers B., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)

Cross-references
Cell line collections JCRB; JCRB0177.1
JCRB; NIHS0274.1 - Discontinued
Cell line databases/resources CCLE; KP1NL_PANCREAS
CGH-DB; 174-1
CGH-DB; 9369-4
LINCS_LDP; LCL-1794
Gene expression databases GEO; GSM1588617
Polymorphism and mutation databases Cosmic; 918048