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Cellosaurus KP-1NL (CVCL_3003)

[Text version]

Cell line name KP-1NL
Synonyms KP-1N-L; KP-1-NL; KP1-NL; KP1NL
Accession CVCL_3003
Resource Identification Initiative To cite this cell line use: KP-1NL (RRID:CVCL_3003)
Comments Problematic cell line: Contaminated. Parent cell line (KP-1N) has been shown to be a PANC-1 derivative.
Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: 25 hours (PubMed=25984343).
Omics: Deep exome analysis.
Omics: shRNA library screening.
Omics: Transcriptome analysis.
Sequence variations Homozygous for CDKN2A deletion (from parent cell line).
Heterozygous for KRAS p.Gly12Asp (c.35G>A) (PubMed=21607521; CCLE).
Homozygous for TP53 p.Arg273His (c.818G>A) (PubMed=21607521; CCLE).
Disease Pancreatic ductal adenocarcinoma (NCIt: C9120)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_3002 (KP-1N)
Children:
CVCL_4Y21 (KP-1NL-Luc#2)
Sex of cell Male
Age at sampling 56Y
Category Cancer cell line
STR profile Source(s): JCRB

Markers:
AmelogeninX
CSF1PO10,12
D5S81811,13
D7S8208,10
D13S31711
D16S53911
TH017,8
TPOX8,11
vWA15

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Publications

PubMed=2172194; DOI=10.1111/j.1349-7006.1990.tb03336.x
Ikeda Y., Ezaki M., Hayashi I., Yasuda D., Nakayama K., Kono A.
Establishment and characterization of human pancreatic cancer cell lines in tissue culture and in nude mice.
Jpn. J. Cancer Res. 81:987-993(1990)

PubMed=21607521; DOI=10.3892/or.1.6.1223
Iguchi H., Morita R., Yasuda D., Takayanagi R., Ikeda Y., Takada Y., Shimazoe T., Nawata H., Kono A.
Alterations of the p53 tumor-suppressor gene and ki-ras oncogene in human pancreatic cancer-derived cell-lines with different metastatic potential.
Oncol. Rep. 1:1223-1227(1994)

PubMed=18380791; DOI=10.1111/j.1349-7006.2008.00779.x
Suzuki A., Shibata T., Shimada Y., Murakami Y., Horii A., Shiratori K., Hirohashi S., Inazawa J., Imoto I.
Identification of SMURF1 as a possible target for 7q21.3-22.1 amplification detected in a pancreatic cancer cell line by in-house array-based comparative genomic hybridization.
Cancer Sci. 99:986-994(2008)

PubMed=25984343; DOI=10.1038/sdata.2014.35
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Hill Meyers B., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections JCRB; JCRB0177.1
JCRB; NIHS0274.1 - Discontinued
Cell line databases/resources CCLE; KP1NL_PANCREAS
CGH-DB; 174-1
CGH-DB; 9369-4
DepMap; ACH-001108
LINCS_LDP; LCL-1794
Biological sample resources BioSample; SAMN10989577
Chemistry resources PharmacoDB; KP1NL_782_2019
Gene expression databases GEO; GSM1588617
GEO; GSM1588629
Other Wikidata; Q54900357
Polymorphism and mutation databases Cosmic; 918048
IARC_TP53; 30108
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number22