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Cellosaurus KP-1NL (CVCL_3003)

Cell line name KP-1NL
Synonyms KP-1N-L; KP-1-NL; KP1-NL; KP1NL
Accession CVCL_3003
Resource Identification Initiative To cite this cell line use: KP-1NL (RRID:CVCL_3003)
Comments Problematic cell line: Contaminated. Parent cell line (KP-1N) has been shown to be a PANC-1 derivative.
Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: 25 hours (PubMed=25984343).
Omics: shRNA library screening.
Omics: Transcriptome analysis.
Sequence variations Homozygous for CDKN2A deletion (from parent cell line).
KRAS p.Gly12Asp (c.35G>A) (from parent cell line).
TP53 p.Arg273His (c.818G>A) (from parent cell line).
Disease Pancreatic ductal adenocarcinoma (NCIt: C9120)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_3002 (KP-1N)
CVCL_4Y21 (KP-1NL-Luc#2)
Sex of cell Male
Age at sampling 56Y
Category Cancer cell line
STR profile Source(s): JCRB


PubMed=2172194; DOI=10.1111/j.1349-7006.1990.tb03336.x
Ikeda Y., Ezaki M., Hayashi I., Yasuda D., Nakayama K., Kono A.
Establishment and characterization of human pancreatic cancer cell lines in tissue culture and in nude mice.
Jpn. J. Cancer Res. 81:987-993(1990)

PubMed=18380791; DOI=10.1111/j.1349-7006.2008.00779.x
Suzuki A., Shibata T., Shimada Y., Murakami Y., Horii A., Shiratori K., Hirohashi S., Inazawa J., Imoto I.
Identification of SMURF1 as a possible target for 7q21.3-22.1 amplification detected in a pancreatic cancer cell line by in-house array-based comparative genomic hybridization.
Cancer Sci. 99:986-994(2008)

PubMed=25984343; DOI=10.1038/sdata.2014.35
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Hill Meyers B., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)

Cell line collections JCRB; JCRB0177.1
JCRB; NIHS0274.1 - Discontinued
Cell line databases/resources CCLE; KP1NL_PANCREAS
CGH-DB; 174-1
CGH-DB; 9369-4
Gene expression databases GEO; GSM1588617
GEO; GSM1588629
Other Wikidata; Q54900357
Polymorphism and mutation databases Cosmic; 918048