Cellosaurus LC-1/sq (CVCL_3008)

Cell line name LC-1/sq
Synonyms LC-1 sq; LC-1-sq; LC-1Sq; LC1/Sq; LC1-Sq; LC1-sq; LC1sq; Lc1sq; LC1SQ; Lung cancer-1/squamous; LC-1
Accession CVCL_3008
Resource Identification Initiative To cite this cell line use: LC-1/sq (RRID:CVCL_3008)
Comments Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: Transcriptome analysis.
Disease Squamous cell lung carcinoma (NCIt: C3493)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children: CVCL_5480 (LC-1/sq-SF)
Originate from same individual CVCL_1372 ! LC-1F
Sex of cell Male
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB; RCB

Markers:
AmelogeninX
CSF1PO12
D13S31712,13
D16S5399
D5S81812,13
D7S82012
TH017,9
TPOX8,12
vWA17,18
Publications

PubMed=1917142; DOI=10.1002/ijc.2910490322
Itoh H., Kataoka H., Koita H., Nabeshima K., Inoue T., Kangawa K., Koono M.
Establishment of a new human cancer cell line secreting protease nexin-II/amyloid beta protein precursor derived from squamous-cell carcinoma of lung.
Int. J. Cancer 49:436-443(1991)

PubMed=11005564; DOI=10.1038/sj.neo.7900094
Kohno T., Sato T., Takakura S., Takei K., Inoue K., Nishioka M., Yokota J.
Mutation and expression of the DCC gene in human lung cancer.
Neoplasia 2:300-305(2000)

PubMed=14581340
Yokoi S., Yasui K., Iizasa T., Imoto I., Fujisawa T., Inazawa J.
TERC identified as a probable target within the 3q26 amplicon that is detected frequently in non-small cell lung cancers.
Clin. Cancer Res. 9:4705-4713(2003)

PubMed=15185009; DOI=10.1007/s00262-004-0533-9
Yamaji H., Iizasa T., Koh E., Suzuki M., Otsuji M., Chang H., Motohashi S., Yokoi S., Hiroshima K., Tagawa M., Nakayama T., Fujisawa T.
Correlation between interleukin 6 production and tumor proliferation in non-small cell lung cancer.
Cancer Immunol. Immunother. 53:786-792(2004)

PubMed=15746151; DOI=10.1093/hmg/ddi092
Izumi H., Inoue J., Yokoi S., Hosoda H., Shibata T., Sunamori M., Hirohashi S., Inazawa J., Imoto I.
Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers.
Hum. Mol. Genet. 14:997-1007(2005)

PubMed=19472407; DOI=10.1002/humu.21028
Blanco R., Iwakawa R., Tang M., Kohno T., Angulo B., Pio R., Montuenga L.M., Minna J.D., Yokota J., Sanchez-Cespedes M.
A gene-alteration profile of human lung cancer cell lines.
Hum. Mutat. 30:1199-1206(2009)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections JCRB; JCRB0258
RCB; RCB0455
Cell line databases/resources CGH-DB; 188-1
CGH-DB; 9178-4
Cosmic-CLP; 1298223
GDSC; 1298223
LINCS_LDP; LCL-1586
Ontologies CLO; CLO_0050045
Biological sample resources BioSample; SAMN03471667
Gene expression databases GEO; GSM784280
GEO; GSM827201
GEO; GSM1374618
GEO; GSM1670042
Polymorphism and mutation databases Cosmic; 713858
Cosmic; 801579
Cosmic; 844843
Cosmic; 876169
Cosmic; 889102
Cosmic; 917979
Cosmic; 929146
Cosmic; 932926
Cosmic; 1219072
Cosmic; 1239906