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Cellosaurus LC-1/sq (CVCL_3008)

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Cell line name LC-1/sq
Synonyms LC-1 sq; LC-1-sq; LC-1Sq; LC1/Sq; LC1-Sq; LC1-sq; LC1sq; Lc1sq; LC1SQ; Lung cancer-1/squamous; LC-1; LC1
Accession CVCL_3008
Resource Identification Initiative To cite this cell line use: LC-1/sq (RRID:CVCL_3008)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: 64.6 hours (PubMed=1917142); ~75 hours (lot 11122004) (JCRB).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Heterozygous for SPEN p.Arg1475Ter (c.4423C>T) (CCLE; Cosmic-CLP).
Homozygous for TP53 p.Met237Ile (c.711G>T) (CCLE; Cosmic-CLP).
HLA typing Source: PubMed=9023415
Class I
HLA-AA*11,24:02
HLA-BB*44:03:01
HLA-CC*12:03,16:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.33
Native American0
East Asian, North91.84
East Asian, South7.55
South Asian0.28
European, North0
European, South0
Disease Squamous cell lung carcinoma (NCIt: C3493)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_5480 (LC-1/sq-SF)CVCL_1372 (LC-1F)
Sex of cell Male
Age at sampling 69Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB; RCB

Markers:
AmelogeninX
CSF1PO12
D5S81812,13
D7S82012
D13S31712,13
D16S5399
TH017,9
TPOX8,12
vWA17,18

Run an STR similarity search on this cell line
Publications

PubMed=1917142; DOI=10.1002/ijc.2910490322
Itoh H., Kataoka H., Koita H., Nabeshima K., Inoue T., Kangawa K., Koono M.
Establishment of a new human cancer cell line secreting protease nexin-II/amyloid beta protein precursor derived from squamous-cell carcinoma of lung.
Int. J. Cancer 49:436-443(1991)

PubMed=8348978; DOI=10.1016/0014-5793(93)80946-R
Kataoka H., Seguchi K., Inoue T., Koono M.
Properties of alpha 1-antitrypsin secreted by human adenocarcinoma cell lines.
FEBS Lett. 328:291-295(1993)

PubMed=9023415; DOI=10.1006/cimm.1996.1062
Seki N., Hoshino T., Kikuchi M., Hayashi A., Itoh K.
HLA-A locus-restricted and tumor-specific CTLs in tumor-infiltrating lymphocytes of patients with non-small cell lung cancer.
Cell. Immunol. 175:101-110(1997)

PubMed=11005564; DOI=10.1038/sj.neo.7900094
Kohno T., Sato T., Takakura S., Takei K., Inoue K., Nishioka M., Yokota J.
Mutation and expression of the DCC gene in human lung cancer.
Neoplasia 2:300-305(2000)

PubMed=14581340
Yokoi S., Yasui K., Iizasa T., Imoto I., Fujisawa T., Inazawa J.
TERC identified as a probable target within the 3q26 amplicon that is detected frequently in non-small cell lung cancers.
Clin. Cancer Res. 9:4705-4713(2003)

PubMed=15185009; DOI=10.1007/s00262-004-0533-9
Yamaji H., Iizasa T., Koh E., Suzuki M., Otsuji M., Chang H., Motohashi S., Yokoi S., Hiroshima K., Tagawa M., Nakayama T., Fujisawa T.
Correlation between interleukin 6 production and tumor proliferation in non-small cell lung cancer.
Cancer Immunol. Immunother. 53:786-792(2004)

PubMed=15746151; DOI=10.1093/hmg/ddi092
Izumi H., Inoue J., Yokoi S., Hosoda H., Shibata T., Sunamori M., Hirohashi S., Inazawa J., Imoto I.
Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers.
Hum. Mol. Genet. 14:997-1007(2005)

PubMed=19472407; DOI=10.1002/humu.21028
Blanco R., Iwakawa R., Tang M., Kohno T., Angulo B., Pio R., Montuenga L.M., Minna J.D., Yokota J., Sanchez-Cespedes M.
A gene-alteration profile of human lung cancer cell lines.
Hum. Mutat. 30:1199-1206(2009)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=24002593; DOI=10.1038/bjc.2013.452
Wu D., Pang Y., Wilkerson M.D., Wang D., Hammerman P.S., Liu J.S.
Gene-expression data integration to squamous cell lung cancer subtypes reveals drug sensitivity.
Br. J. Cancer 109:1599-1608(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections JCRB; JCRB0258
RCB; RCB0455
Cell line databases/resources CCLE; LC1_LUNG
Cell_Model_Passport; SIDM00300
CGH-DB; 188-1
CGH-DB; 9178-4
Cosmic-CLP; 1298223
DepMap; ACH-002156
LINCS_LDP; LCL-1586
Ontologies CLO; CLO_0050045
Biological sample resources BioSample; SAMN03471667
Chemistry resources GDSC; 1298223
PharmacoDB; LC1sq_828_2019
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM784280
GEO; GSM827201
GEO; GSM1374618
GEO; GSM1670042
Other Wikidata; Q54902121
Polymorphism and mutation databases Cosmic; 713858
Cosmic; 801579
Cosmic; 844843
Cosmic; 876169
Cosmic; 889102
Cosmic; 917979
Cosmic; 929146
Cosmic; 932926
Cosmic; 1219072
Cosmic; 1239906
Cosmic; 2668326
IARC_TP53; 2382
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number24