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Cellosaurus LLC-MK2 (CVCL_3009)

[Text version]

Cell line name LLC-MK2
Synonyms Llc-Mk2; LLC-MK-2; LLCMK2; LLcMK2; Lilly Laboratories Cell-Monkey Kidney 2
Accession CVCL_3009
Resource Identification Initiative To cite this cell line use: LLC-MK2 (RRID:CVCL_3009)
Comments Group: Non-human primate cell line.
Characteristics: Derived from the trypsinization of a pool of kidneys from 6 adult rhesus monkeys.
Characteristics: Susceptible to SARS coronavirus (SARS-CoV) infection (PubMed=16494729).
Derived from sampling site: Kidney.
Species of origin Macaca mulatta (Rhesus macaque) (NCBI Taxonomy: 9544)
Hierarchy Children:
CVCL_U988 (NCTC 3196)CVCL_3069 (NCTC 3526)
Age at sampling Adult
Category Spontaneously immortalized cell line
Web pages http://fluoview.magnet.fsu.edu/gallery/cells/llcmk2/llcmk2cells.html

PubMed=13821019; DOI=10.1093/oxfordjournals.aje.a120078
Evans V.J., Kerr H.A., McQuilkin W.T., Earle W.R., Hull R.N.
Growth in vitro of a long-term strain of monkey-kidney cells in medium NCTC 109 free of any added protein.
Am. J. Hyg. 70:297-302(1959)

PubMed=14449901; DOI=10.1084/jem.115.5.903
Hull R.N., Cherry W.R., Tritch O.J.
Growth characteristics of monkey kidney cell strains LLC-MK1, LLC-MK2, and LLC-MK2(NCTC-3196) and their utility in virus research.
J. Exp. Med. 115:903-918(1962)

PubMed=14185313; DOI=10.1126/science.146.3641.241
Cell Culture Collection Committee
Animal cell strains. The Cell Culture Collection Committee has assembled and certified 23 strains of animal cells.
Science 146:241-243(1964)

PubMed=18605421; DOI=10.1093/jnci/45.5.951
Ikeuchi T., Sandberg A.A.
Chromosome pulverization in virus-induced heterokaryons of mammalian cells from different species.
J. Natl. Cancer Inst. 45:951-963(1970)

Petricciani J.C., Wallace R.E., McCoy D.W.
A comparison of three in vivo assays for cell tumorigenicity.
Cancer Res. 34:105-108(1974)

PubMed=6298990; DOI=10.1016/0378-1135(82)90056-6
McPhee D.A., Parsonson I.M., Della-Porta A.J.
Comparative studies on the growth of Australian bluetongue virus serotypes in continuous cell lines and embryonated chicken eggs.
Vet. Microbiol. 7:401-410(1982)

PubMed=16494729; DOI=10.3201/eid1201.050496
Kaye M., Druce J., Tran T., Kostecki R., Chibo D., Morris J., Catton M., Birch C.
SARS-associated coronavirus replication in cell lines.
Emerg. Infect. Dis. 12:128-133(2006)

Cell line collections AddexBio; P0014004/4952
BCRC; 60092
BCRC; 60365
BCRJ; 0146
ECACC; 85062804
Cell line databases/resources CLDB; cl3214
CLDB; cl3215
CLDB; cl3218
CLDB; cl3219
CLDB; cl3220
CCRID; 3111C0002000000078
CCRID; 3131C0001000400006
Lonza; 128
Ontologies CLO; CLO_0007330
Chemistry resources ChEMBL-Cells; CHEMBL3307684
ChEMBL-Targets; CHEMBL614691
Other Wikidata; Q54902701
Entry history
Entry creation04-Apr-2012
Last entry update12-Mar-2020
Version number22