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Cellosaurus Lu-99 (CVCL_3015)

[Text version]

Cell line name Lu-99
Synonyms LU-99; Lu 99; Lu99; LU99; C-Lu99
Accession CVCL_3015
Resource Identification Initiative To cite this cell line use: Lu-99 (RRID:CVCL_3015)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: NCI RAS program mutant KRAS cell line panel.
Doubling time: 21.1 hours (lot 061891), ~25 hours (lot 10092014) (JCRB).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Heterozygous for KRAS p.Gly12Cys (c.34G>T) (CCLE).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.25
Native American0
East Asian, North84.63
East Asian, South13.5
South Asian0
European, North0
European, South1.62
Disease Lung giant cell carcinoma (NCIt: C4452)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_1393 (Lu-99A)CVCL_2801 (Lu-99B)CVCL_2802 (Lu-99C)
Sex of cell Male
Age at sampling 63Y
Category Cancer cell line
STR profile Source(s): JCRB; RCB; TKG

Markers:
AmelogeninX
CSF1PO10,15
D5S81812
D7S82011
D13S31710,11
D16S5399
TH019
TPOX11
vWA18

Run an STR similarity search on this cell line
Publications

PubMed=3935627; DOI=10.20772/cancersci1985.76.10_967
Yamada T., Hirohashi S., Shimosato Y., Kodama T., Hayashi S., Ogura T., Gamou S., Shimizu N.
Giant cell carcinomas of the lung producing colony-stimulating factor in vitro and in vivo.
Jpn. J. Cancer Res. 76:967-976(1985)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=11005564; DOI=10.1038/sj.neo.7900094
Kohno T., Sato T., Takakura S., Takei K., Inoue K., Nishioka M., Yokota J.
Mutation and expression of the DCC gene in human lung cancer.
Neoplasia 2:300-305(2000)

PubMed=12569360; DOI=10.1038/sj.onc.1206106
Funakoshi T., Tachibana I., Hoshida Y., Kimura H., Takeda Y., Kijima T., Nishino K., Goto H., Yoneda T., Kumagai T., Osaki T., Hayashi S., Aozasa K., Kawase I.
Expression of tetraspanins in human lung cancer cells: frequent downregulation of CD9 and its contribution to cell motility in small cell lung cancer.
Oncogene 22:674-687(2003)

PubMed=16105816; DOI=10.1158/0008-5472.CAN-05-0331
Nagai Y., Miyazawa H., Huqun X., Tanaka T., Udagawa K., Kato M., Fukuyama S., Yokote A., Kobayashi K., Kanazawa M., Hagiwara K.
Genetic heterogeneity of the epidermal growth factor receptor in non-small cell lung cancer cell lines revealed by a rapid and sensitive detection system, the peptide nucleic acid-locked nucleic acid PCR clamp.
Cancer Res. 65:7276-7282(2005)

PubMed=22313637; DOI=10.4161/cbt.19238
Takata M., Chikumi H., Miyake N., Adachi K., Kanamori Y., Yamasaki A., Igishi T., Burioka N., Nanba E., Shimizu E.
Lack of AKT activation in lung cancer cells with EGFR mutation is a novel marker of cetuximab sensitivity.
Cancer Biol. Ther. 13:369-378(2012)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections JCRB; JCRB0080
RCB; RCB1900
TKG; TKG 0495
Cell line databases/resources CCLE; LU99_LUNG
Cell_Model_Passport; SIDM00546
DepMap; ACH-000444
Ontologies BTO; BTO:0006141
CLO; CLO_0050038
Biological sample resources BioSample; SAMN03471066
BioSample; SAMN10987825
Chemistry resources ChEMBL-Cells; CHEMBL3308600
ChEMBL-Targets; CHEMBL614651
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM887283
GEO; GSM888358
Other Wikidata; Q54903211
Polymorphism and mutation databases Cosmic; 801578
Cosmic; 808503
Cosmic; 844828
Cosmic; 876174
Cosmic; 946068
Cosmic; 1048224
Cosmic; 1571756
Cosmic; 1656907
Cosmic; 2125270
LiGeA; CCLE_430
Entry history
Entry creation04-Apr-2012
Last entry updated05-Jul-2019
Version number19