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Cellosaurus NC-37 (CVCL_3042)

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Cell line name NC-37
Synonyms NC 37; NC37; Nc37
Accession CVCL_3042
Resource Identification Initiative To cite this cell line use: NC-37 (RRID:CVCL_3042)
Comments Problematic cell line: Contaminated. Shown to be a Raji derivative (PubMed=20143388).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00330.
Population: African; Nigerian.
Doubling time: ~20 hours (NIH-ARP).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: SNP array analysis.
Derived from sampling site: Jaw.
Sequence variations MYC-IGH gene fusion (from parent cell line).
Heterozygous for TP53 p.Arg213Gln (c.638G>A) (ClinVar=VCV000135359) and p.Tyr234His (c.700T>C) (from parent cell line).
Disease EBV-related Burkitt lymphoma (NCIt: C27694)
Burkitt lymphoma (ORDO: Orphanet_543)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0511 (Raji)
Sex of cell Male
Age at sampling 11Y
Category Cancer cell line
STR profile Source(s): ATCC; JCRB; TKG

D13S31713,14 (ATCC)
13 (JCRB; TKG)
vWA16 (ATCC)
16,19 (JCRB; TKG)

Run an STR similarity search on this cell line
Web pages http://cellbank.nibiohn.go.jp/legacy/cellbank/qualitycontrol/identification/summary.htm

Minowada J., Nonoyama M., Moore G.E., Rauch A.M., Pagano J.S.
The presence of the Epstein-Barr viral genome in human lymphoblastoid B-cell lines and its absence in a myeloma cell line.
Cancer Res. 34:1898-1903(1974)

PubMed=165156; DOI=10.1002/ijc.2910150217
Nilsson K., Ponten J.
Classification and biological nature of established human hematopoietic cell lines.
Int. J. Cancer 15:321-341(1975)

PubMed=170370; DOI=10.1099/0022-1317-28-2-207
Adams A., Strander H., Cantell K.
Sensitivity of the Epstein-Barr virus transformed human lymphoid cell lines to interferon.
J. Gen. Virol. 28:207-217(1975)

PubMed=6500159; DOI=10.1159/000163283
Gershwin M.E., Lentz D., Owens R.B.
Relationship between karyotype of tissue culture lines and tumorigenicity in nude mice.
Exp. Cell Biol. 52:361-370(1984)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=29892436; DOI=10.1098/rsos.172472
Shioda S., Kasai F., Watanabe K., Kawakami K., Ohtani A., Iemura M., Ozawa M., Arakawa A., Hirayama N., Kawaguchi E., Tano T., Miyata S., Satoh M., Shimizu N., Kohara A.
Screening for 15 pathogenic viruses in human cell lines registered at the JCRB Cell Bank: characterization of in vitro human cells by viral infection.
R. Soc. Open Sci. 5:172472-172472(2018)

Cell line collections ATCC; CCL-214
ECACC; 89111414 - Discontinued
JCRB; IFO50039
KCLB; 10214 - Discontinued
NCBI_Iran; C501
NIH-ARP; 9936-272
RCB; RCB3008
TKG; TKG 0232
Cell line databases/resources CLDB; cl3648
CLDB; cl3649
Cell_Model_Passport; SIDM01207
IGRhCellID; NC37
Ontologies BTO; BTO:0005495
CLO; CLO_0007952
EFO; EFO_0002247
Biological sample resources BioSample; SAMN03151899
BioSample; SAMN03471475
Chemistry resources ChEMBL-Cells; CHEMBL3307322
ChEMBL-Targets; CHEMBL614189
Other Wikidata; Q54907589
Polymorphism and mutation databases Cosmic; 687848
Entry history
Entry creation04-Apr-2012
Last entry updated02-Jul-2020
Version number23