Home  |  Contact

Cellosaurus OSC-19 (CVCL_3086)

[Text version]

Cell line name OSC-19
Synonyms OSC19; Osc19
Accession CVCL_3086
Resource Identification Initiative To cite this cell line use: OSC-19 (RRID:CVCL_3086)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Part of: MD Anderson Cell Lines Project.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.1
Native American0.32
East Asian, North72.98
East Asian, South24.24
South Asian0.65
European, North1.7
European, South0.01
Disease Tongue squamous cell carcinoma (NCIt: C4648)
Derived from metastatic site: Cervical lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_AT74 (OSC-19LN1)
Sex of cell Male
Age at sampling 61Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB; PubMed=21868764

Markers:
AmelogeninX,Y
CSF1PO12
D5S81810,13
D7S8209,11
D13S31712
D16S5399,12
TH019
TPOX11
vWA14 (Cosmic-CLP; JCRB)
14,18 (PubMed=21868764)

Run an STR similarity search on this cell line
Web pages http://tcpaportal.org/mclp/
Publications

CLPUB00295
Yokoi T., Homma H., Odajima T.
Establishment and characterization of OSC-19 cell line in serum- and protein-free culture.
Tumor Res. 24:57-73(1989)

CLPUB00296
Yokoi T., Yamaguchi A., Tetsuyo O., Kazunori F.
Establishment and characterization of a human cell line derived from a squamous cell carcinoma of the tongue.
Tumor Res. 23:43-57(1989)

CLPUB00244
Yonekura N., Yokosawa N., Hariya Y., Dehari H., Kohama G.-I., Fujii N.
Interferon-alpha and interferon-gamma augment apoptosis in oral carcinoma cells treated with Shiga toxin 2 (Stx2).
Tumor Res. 35:25-33(2000)

PubMed=19123955; DOI=10.1186/1479-5876-7-1
Kobayashi J.-I., Torigoe T., Hirohashi Y., Idenoue S., Miyazaki A., Yamaguchi A., Hiratsuka H., Sato N.
Comparative study on the immunogenicity between an HLA-A24-restricted cytotoxic T-cell epitope derived from survivin and that from its splice variant survivin-2B in oral cancer patients.
J. Transl. Med. 7:1-1(2009)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690
Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C., Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G., Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

PubMed=26754630; DOI=10.1186/s13046-016-0284-4
Hyakusoku H., Sano D., Takahashi H., Hatano T., Isono Y., Shimada S., Ito Y., Myers J.N., Oridate N.
JunB promotes cell invasion, migration and distant metastasis of head and neck squamous cell carcinoma.
J. Exp. Clin. Cancer Res. 35:6-6(2016)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=29156801; DOI=10.18632/oncotarget.21174
Kalu N.N., Mazumdar T., Peng S., Shen L., Sambandam V., Rao X., Xi Y., Li L., Qi Y., Gleber-Netto F.O., Patel A., Wang J., Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Oncotarget 8:86369-86383(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections JCRB; JCRB0198
JCRB; FDSC0050 - Discontinued
Cell line databases/resources CCLE; OSC19_UPPER_AERODIGESTIVE_TRACT
Cell_Model_Passport; SIDM00566
Cosmic-CLP; 1298362
DepMap; ACH-001625
GDSC; 1298362
LINCS_LDP; LCL-1219
Biological sample resources BioSample; SAMN03471655
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM1670308
Other Wikidata; Q54936575
Polymorphism and mutation databases Cosmic; 1120701
Entry history
Entry creation04-Apr-2012
Last entry updated05-Jul-2019
Version number21