Cellosaurus OSC-19 (CVCL_3086)

Cell line name OSC-19
Synonyms OSC19; Osc19
Accession CVCL_3086
Resource Identification Initiative To cite this cell line use: OSC-19 (RRID:CVCL_3086)
Comments Part of: COSMIC cell lines project.
Part of: MD Anderson Cell Lines Project.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Disease Tongue squamous cell carcinoma (NCIt: C4648)
Derived from metastatic site: Cervical lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_AT74 (OSC-19LN1)
Sex of cell Male
Age at sampling 61Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB; PubMed=21868764

Markers:
AmelogeninX,Y
CSF1PO12
D13S31712
D16S5399,12
D5S81810,13
D7S8209,11
TH019
TPOX11
vWA14 (Cosmic-CLP; JCRB)
14,18 (PubMed=21868764)
Web pages http://tcpaportal.org/mclp/
Publications

CLPUB00295
Yokoi T., Homma H., Odajima T.
Establishment and characterization of OSC-19 cell line in serum- and protein-free culture.
Tumor Res. 24:57-73(1989)

CLPUB00296
Yokoi T., Yamaguchi A., Tetsuyo O., Kazunori F.
Establishment and characterization of a human cell line derived from a squamous cell carcinoma of the tongue.
Tumor Res. 23:43-57(1989)

CLPUB00244
Yonekura N., Yokosawa N., Hariya Y., Dehari H., Kohama G.-I., Fujii N.
Interferon-alpha and interferon-gamma augment apoptosis in oral carcinoma cells treated with Shiga toxin 2 (Stx2).
Tumor Res. 35:25-33(2000)

PubMed=19123955; DOI=10.1186/1479-5876-7-1
Kobayashi J.-I., Torigoe T., Hirohashi Y., Idenoue S., Miyazaki A., Yamaguchi A., Hiratsuka H., Sato N.
Comparative study on the immunogenicity between an HLA-A24-restricted cytotoxic T-cell epitope derived from survivin and that from its splice variant survivin-2B in oral cancer patients.
J. Transl. Med. 7:1-1(2009)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690
Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C., Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G., Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

PubMed=26754630; DOI=10.1186/s13046-016-0284-4
Hyakusoku H., Sano D., Takahashi H., Hatano T., Isono Y., Shimada S., Ito Y., Myers J.N., Oridate N.
JunB promotes cell invasion, migration and distant metastasis of head and neck squamous cell carcinoma.
J. Exp. Clin. Cancer Res. 35:6-6(2016)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references
Cell line collections JCRB; JCRB0198
Cell line databases/resources Cosmic-CLP; 1298362
GDSC; 1298362
LINCS_LDP; LCL-1219
Biological sample resources BioSample; SAMN03471655
Gene expression databases GEO; GSM1670308
Polymorphism and mutation databases Cosmic; 1120701