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Cellosaurus OSC-20 (CVCL_3087)

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Cell line name OSC-20
Synonyms OSC20
Accession CVCL_3087
Resource Identification Initiative To cite this cell line use: OSC-20 (RRID:CVCL_3087)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Population: Japanese.
Doubling time: 27.4 hours, at 35th passage (DOI=10.15114/tr.25.93); ~49 hours (lot 11152011), 65 hours (lot 02032003) (JCRB).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Mutation; HGNC; 1787; CDKN2A; Simple; p.Pro81Leu (c.242C>T); Zygosity=Homozygous (CCLE; Cosmic-CLP).
Mutation; HGNC; 8975; PIK3CA; Simple; p.His1048Arg (c.3143A>G); ClinVar=VCV000450316; Zygosity=Heterozygous (CCLE; Cosmic-CLP).
Mutation; HGNC; 11998; TP53; Simple; p.Arg249Ser (c.747G>T); ClinVar=VCV000012352; Zygosity=Homozygous (CCLE; Cosmic-CLP).
HLA typing Source: PubMed=9119748
Class I
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0.23
East Asian, North75.72
East Asian, South16.66
South Asian0
European, North0
European, South4.24
Disease Tongue squamous cell carcinoma (NCIt: C4648)
Squamous cell carcinoma of the oral tongue (ORDO: Orphanet_457252)
Derived from metastatic site: Cervical lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_WW78 ! TcOSC-20
Sex of cell Female
Age at sampling 59Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DepMap

D5S81813 (Cosmic-CLP)
13,14 (DepMap)
Penta D9,12
Penta E14,16

Run an STR similarity search on this cell line

Yokoi T., Hirata S., Nishimura F., Miyakawa A., Odajima T., Kohama G.-I., Mochizuki Y.
Some properties of a newly established human cell line from a oral squamous carcinoma.
Tumor Res. 25:93-103(1990)

PubMed=9119748; DOI=10.1111/j.1349-7006.1997.tb00365.x
Miyazaki A., Sato N., Takahashi S., Sasaki A., Kohama G.-I., Yamaguchi A., Yagihashi A., Kikuchi K.
Cytotoxicity of histocompatibility leukocyte antigen-DR8-restricted CD4 killer T cells against human autologous squamous cell carcinoma.
Jpn. J. Cancer Res. 88:191-197(1997)

Yonekura N., Yokosawa N., Hariya Y., Dehari H., Kohama G.-I., Fujii N.
Interferon-alpha and interferon-gamma augment apoptosis in oral carcinoma cells treated with Shiga toxin 2 (Stx2).
Tumor Res. 35:25-33(2000)

PubMed=12716470; DOI=10.1111/j.1349-7006.2002.tb01338.x
Kondo H., Sahara H., Miyazaki A., Nabeta Y., Hirohashi Y., Kanaseki T., Yamaguchi A., Yamada N., Hirayama K., Suzuki M., Hamuro J., Torigoe T., Takahashi N., Kohama G.-I., Ikeda H., Sato N.
Natural antigenic peptides from squamous cell carcinoma recognized by autologous HLA-DR8-restricted CD4+ T cells.
Jpn. J. Cancer Res. 93:917-924(2002)

PubMed=19123955; DOI=10.1186/1479-5876-7-1
Kobayashi J.-I., Torigoe T., Hirohashi Y., Idenoue S., Miyazaki A., Yamaguchi A., Hiratsuka H., Sato N.
Comparative study on the immunogenicity between an HLA-A24-restricted cytotoxic T-cell epitope derived from survivin and that from its splice variant survivin-2B in oral cancer patients.
J. Transl. Med. 7:1.1-1.11(2009)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cell line collections JCRB; JCRB0197
JCRB; FDSC0051 - Discontinued
Cell line databases/resources CCLE; OSC20_UPPER_AERODIGESTIVE_TRACT
Cell_Model_Passport; SIDM00565
Cosmic-CLP; 1240196
DepMap; ACH-001626
Chemistry resources GDSC; 1240196
PharmacoDB; OSC20_1206_2019
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM827220
GEO; GSM1670309
Other Wikidata; Q54936583
Polymorphism and mutation databases Cosmic; 1120702
Cosmic; 1995604
Progenetix; CVCL_3087
Entry history
Entry creation04-Apr-2012
Last entry update20-May-2021
Version number26