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Cellosaurus OVMIU (CVCL_3112)

[Text version]

Cell line name OVMIU
Accession CVCL_3112
Resource Identification Initiative To cite this cell line use: OVMIU (RRID:CVCL_3112)
Comments Problematic cell line: Contaminated. Shown to be a OVSAYO derivative (PubMed=20143388).
Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00341.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Heterozygous for TP53 p.Arg249Met (c.746G>T) (from parent cell line).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.26
Native American0.2
East Asian, North75.07
East Asian, South23.44
South Asian1.02
European, North0
European, South0
Disease High grade ovarian serous adenocarcinoma (NCIt: C105555)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_3115 (OVSAYO)
Sex of cell Female
Age at sampling 64Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB

Markers:
AmelogeninX
CSF1PO12
D5S81811,12
D7S82010,12
D13S3178,11
D16S5399,10
TH017
TPOX9,11
vWA17,18

Run an STR similarity search on this cell line
Web pages http://cellbank.nibiohn.go.jp/legacy/cellbank/qualitycontrol/identification/summary.htm
http://iclac.org/wp-content/uploads/Cross-Contaminations_v9_distribution.xlsx
Publications

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections JCRB; JCRB1049
JCRB; NIHS0302 - Discontinued
JCRB; NIHS0344 - Discontinued
Cell line databases/resources CCLE; OVMIU_OVARY
Cell_Model_Passport; SIDM00465
Cosmic-CLP; 1240200
DepMap; ACH-002183
GDSC; 1240200
LINCS_LDP; LCL-1526
Biological sample resources BioSample; SAMN03151882
BioSample; SAMN03472489
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM827252
GEO; GSM1670324
Other Wikidata; Q54937032
Polymorphism and mutation databases Cosmic; 1995608
Entry history
Entry creation04-Apr-2012
Last entry updated05-Jul-2019
Version number23