Cellosaurus RERF-LC-OK (CVCL_3154)

Cell line name RERF-LC-OK
Synonyms RERF-LCOK; RERFLCOK; LC-OK; LCOK
Accession CVCL_3154
Resource Identification Initiative To cite this cell line use: RERF-LC-OK (RRID:CVCL_3154)
Comments Problematic cell line: Contaminated. Shown to be a Marcus derivative (PubMed=20143388). Was originally thought to originate from a lung carcinoma.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Misspelling: PERF-LC-OK; In Cosmic 2125286.
Misspelling: REAF-LC-OK; In Cosmic 1571720.
Disease Astrocytoma (NCIt: C60781)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_3019 (Marcus)
Sex of cell Female
Category Cancer cell line
STR profile Source(s): JCRB; PubMed=25877200

Markers:
AmelogeninX
CSF1PO12,15
D13S31711
D16S53912,13
D18S5115
D21S1129
D3S135815,16
D5S81811,12
D7S8209,11
D8S117913,14
FGA20
Penta D15
Penta E12,20
TH019,9.3
TPOX8,11
vWA17
Web pages http://cellbank.nibiohn.go.jp/legacy/cellbank/qualitycontrol/identification/summary.htm
http://iclac.org/wp-content/uploads/Cross-Contaminations-v8_0.pdf
Publications

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=11005564; DOI=10.1038/sj.neo.7900094
Kohno T., Sato T., Takakura S., Takei K., Inoue K., Nishioka M., Yokota J.
Mutation and expression of the DCC gene in human lung cancer.
Neoplasia 2:300-305(2000)

PubMed=14581340
Yokoi S., Yasui K., Iizasa T., Imoto I., Fujisawa T., Inazawa J.
TERC identified as a probable target within the 3q26 amplicon that is detected frequently in non-small cell lung cancers.
Clin. Cancer Res. 9:4705-4713(2003)

PubMed=15185009; DOI=10.1007/s00262-004-0533-9
Yamaji H., Iizasa T., Koh E., Suzuki M., Otsuji M., Chang H., Motohashi S., Yokoi S., Hiroshima K., Tagawa M., Nakayama T., Fujisawa T.
Correlation between interleukin 6 production and tumor proliferation in non-small cell lung cancer.
Cancer Immunol. Immunother. 53:786-792(2004)

PubMed=15746151; DOI=10.1093/hmg/ddi092
Izumi H., Inoue J., Yokoi S., Hosoda H., Shibata T., Sunamori M., Hirohashi S., Inazawa J., Imoto I.
Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers.
Hum. Mol. Genet. 14:997-1007(2005)

PubMed=19472407; DOI=10.1002/humu.21028
Blanco R., Iwakawa R., Tang M., Kohno T., Angulo B., Pio R., Montuenga L.M., Minna J.D., Yokota J., Sanchez-Cespedes M.
A gene-alteration profile of human lung cancer cell lines.
Hum. Mutat. 30:1199-1206(2009)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

Cross-references
Cell line collections JCRB; JCRB0811 - Discontinued
Cell line databases/resources CGH-DB; 207-1
CGH-DB; 9167-4
Ontologies EFO; EFO_0006744
Biological sample resources BioSample; SAMN03151836
BioSample; SAMN03471743
Gene expression databases GEO; GSM274667
Polymorphism and mutation databases Cosmic; 753609
Cosmic; 801580
Cosmic; 876139
Cosmic; 889096
Cosmic; 917974
Cosmic; 932927
Cosmic; 934469
Cosmic; 946065
Cosmic; 1066168
Cosmic; 1219088
Cosmic; 1239899
Cosmic; 1571720
Cosmic; 2125286