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Cellosaurus SCCH-196 (CVCL_3161)

[Text version]

Cell line name SCCH-196
Synonyms SCCH196
Accession CVCL_3161
Resource Identification Initiative To cite this cell line use: SCCH-196 (RRID:CVCL_3161)
Comments Population: Japanese.
Doubling time: ~36 hours (PubMed=2513302); >5 days (lots 08032009 and 11302016) (JCRB).
Omics: DNA methylation analysis.
Omics: Transcriptome analysis.
Sequence variations Gene fusion; HGNC; 3508; EWSR1 + HGNC; 3749; FLI1; Name(s)=EWSR1-FLI1, EWS-FLI1; Note=Type 1 fusion (Ex7/Ex6) (PubMed=7591257; PubMed=9738976).
Disease Ewing sarcoma (NCIt: C4817)
Ewing sarcoma (ORDO: Orphanet_319)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 16Y
Category Cancer cell line
STR profile Source(s): JCRB; TKG

Markers:
AmelogeninX
CSF1PO12
D5S81810,11
D7S8208,11
D13S3178,11
D16S53911,12
TH018,9
TPOX8,11
vWA14,16

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Publications

PubMed=2513302; DOI=10.1111/j.1349-7006.1989.tb01727.x
Homma C., Kaneko Y., Sekine K., Hara S.-I., Hata J.-I., Sakurai M.
Establishment and characterization of a small round cell sarcoma cell line, SCCH-196, with t(11;22)(q24;q12).
Jpn. J. Cancer Res. 80:861-865(1989)

PubMed=8221663
Komuro H., Hayashi Y., Kawamura M., Hayashi K., Kaneko Y., Kamoshita S., Hanada R., Yamamoto K., Hongo T., Yamada M., Tsuchida Y.
Mutations of the p53 gene are involved in Ewing's sarcomas but not in neuroblastomas.
Cancer Res. 53:5284-5288(1993)

PubMed=7591257; DOI=10.1002/ijc.2910630407
Ida K., Kobayashi S., Taki T., Hanada R., Bessho F., Yamamori S., Sugimoto T., Ohki M., Hayashi Y.
EWS-FLI-1 and EWS-ERG chimeric mRNAs in Ewing's sarcoma and primitive neuroectodermal tumor.
Int. J. Cancer 63:500-504(1995)

PubMed=9738976; DOI=10.1111/j.1349-7006.1998.tb03274.x
Urano F., Umezawa A., Yabe H., Hong W., Yoshida K., Fujinaga K., Hata J.-I.
Molecular analysis of Ewing's sarcoma: another fusion gene, EWS-E1AF, available for diagnosis.
Jpn. J. Cancer Res. 89:703-711(1998)

PubMed=12054564; DOI=10.1016/S0006-291X(02)00129-8
Yabe H., Fukuma M., Urano F., Yoshida K., Kato S., Toyama Y., Hata J.-I., Umezawa A.
Lack of matrix metalloproteinase (MMP)-1 and -3 expression in Ewing sarcoma may be due to loss of accessibility of the MMP regulatory element to the specific fusion protein in vivo.
Biochem. Biophys. Res. Commun. 293:61-71(2002)

Cross-references
Cell line collections JCRB; JCRB0108
TKG; TKG 0461
Cell line databases/resources Cell_Model_Passport; SIDM00031
LINCS_LDP; LCL-1403
Chemistry resources PharmacoDB; SCCH196_1358_2019
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM1670413
Other Wikidata; Q54952377
Polymorphism and mutation databases Cosmic; 1078362
Cosmic; 1085907
IARC_TP53; 23592
Entry history
Entry creation04-Apr-2012
Last entry update23-Sep-2021
Version number25