ID   SCCH-196
AC   CVCL_3161
SY   SCCH196
DR   CLO; CLO_0037069
DR   ArrayExpress; E-MTAB-3610
DR   Cell_Model_Passport; SIDM00031
DR   Cosmic; 1078362
DR   Cosmic; 1085907
DR   GEO; GSM1670413
DR   IARC_TP53; 23592
DR   JCRB; JCRB0108
DR   LINCS_LDP; LCL-1403
DR   PharmacoDB; SCCH196_1358_2019
DR   TKG; TKG 0461
DR   Wikidata; Q54952377
RX   PubMed=2513302;
RX   PubMed=7591257;
RX   PubMed=8221663;
RX   PubMed=9738976;
RX   PubMed=12054564;
CC   Population: Japanese.
CC   Doubling time: ~36 hours (PubMed=2513302); >5 days (Note=Lots 08032009 and 11302016) (JCRB=JCRB0108).
CC   Sequence variation: Gene fusion; HGNC; 3508; EWSR1 + HGNC; 3749; FLI1; Name(s)=EWSR1-FLI1, EWS-FLI1; Note=Type 1 fusion (Ex7/Ex6) (PubMed=7591257; PubMed=9738976).
CC   Omics: DNA methylation analysis.
CC   Omics: Transcriptome analysis by microarray.
ST   Source(s): JCRB; TKG
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 8,11
ST   D16S539: 11,12
ST   D5S818: 10,11
ST   D7S820: 8,11
ST   TH01: 8,9
ST   TPOX: 8,11
ST   vWA: 14,16
DI   NCIt; C4817; Ewing sarcoma
DI   ORDO; Orphanet_319; Ewing sarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   16Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 28
//
RX   PubMed=2513302; DOI=10.1111/j.1349-7006.1989.tb01727.x;
RA   Homma C., Kaneko Y., Sekine K.-i., Hara S.-i., Hata J.-i., Sakurai M.;
RT   "Establishment and characterization of a small round cell sarcoma cell
RT   line, SCCH-196, with t(11;22)(q24;q12).";
RL   Jpn. J. Cancer Res. 80:861-865(1989).
//
RX   PubMed=7591257; DOI=10.1002/ijc.2910630407;
RA   Ida K., Kobayashi S., Taki T., Hanada R., Bessho F., Yamamori S.,
RA   Sugimoto T., Ohki M., Hayashi Y.;
RT   "EWS-FLI-1 and EWS-ERG chimeric mRNAs in Ewing's sarcoma and primitive
RT   neuroectodermal tumor.";
RL   Int. J. Cancer 63:500-504(1995).
//
RX   PubMed=8221663;
RA   Komuro H., Hayashi Y., Kawamura M., Hayashi K., Kaneko Y.,
RA   Kamoshita S., Hanada R., Yamamoto K., Hongo T., Yamada M., Tsuchida Y.;
RT   "Mutations of the p53 gene are involved in Ewing's sarcomas but not in
RT   neuroblastomas.";
RL   Cancer Res. 53:5284-5288(1993).
//
RX   PubMed=9738976; DOI=10.1111/j.1349-7006.1998.tb03274.x;
RA   Urano F., Umezawa A., Yabe H., Hong W., Yoshida K., Fujinaga K.,
RA   Hata J.-i.;
RT   "Molecular analysis of Ewing's sarcoma: another fusion gene, EWS-E1AF,
RT   available for diagnosis.";
RL   Jpn. J. Cancer Res. 89:703-711(1998).
//
RX   PubMed=12054564; DOI=10.1016/S0006-291X(02)00129-8;
RA   Yabe H., Fukuma M., Urano F., Yoshida K., Kato S., Toyama Y., Hata J.-i.,
RA   Umezawa A.;
RT   "Lack of matrix metalloproteinase (MMP)-1 and -3 expression in Ewing
RT   sarcoma may be due to loss of accessibility of the MMP regulatory
RT   element to the specific fusion protein in vivo.";
RL   Biochem. Biophys. Res. Commun. 293:61-71(2002).
//