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Cellosaurus SKN-3 (CVCL_3168)

[Text version]

Cell line name SKN-3
Synonyms SKN3
Accession CVCL_3168
Resource Identification Initiative To cite this cell line use: SKN-3 (RRID:CVCL_3168)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Characteristics: Established from a xenograft established in nude mice.
Doubling time: ~40 hours (lot 09012008) (JCRB).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.03
East Asian, North76.9
East Asian, South21.66
South Asian0.86
European, North0.55
European, South0
Disease Head and neck squamous cell carcinoma (NCIt: C34447)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB

Markers:
AmelogeninX
CSF1PO10
D5S8189
D7S82010,11
D13S31711
D16S53910,12
TH019
TPOX9,11
vWA18,20

Run an STR similarity search on this cell line
Publications

PubMed=17599052; DOI=10.1038/sj.onc.1210589
Suzuki E., Imoto I., Pimkhaokham A., Nakagawa T., Kamata N., Kozaki K.-I., Amagasa T., Inazawa J.
PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation.
Oncogene 26:7921-7932(2007)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections JCRB; JCRB1039
Cell line databases/resources CCLE; SKN3_UPPER_AERODIGESTIVE_TRACT
Cell_Model_Passport; SIDM00375
CGH-DB; 370-2
Cosmic-CLP; 1299059
DepMap; ACH-002305
GDSC; 1299059
LINCS_LDP; LCL-1211
Biological sample resources BioSample; SAMN03472486
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM827179
GEO; GSM1670448
Other Wikidata; Q54954755
Polymorphism and mutation databases Cosmic; 1530758
Cosmic; 1530759
Entry history
Entry creation04-Apr-2012
Last entry updated05-Jul-2019
Version number20