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Cellosaurus T.Tn (CVCL_3175)

[Text version]

Cell line name T.Tn
Synonyms T_Tn; T-Tn; TTn; T Tn; T-Tn6; TTN
Accession CVCL_3175
Resource Identification Initiative To cite this cell line use: T.Tn (RRID:CVCL_3175)
Comments Population: Japanese.
Characteristics: Established from the original tumor through transplantation in nude mice.
Doubling time: 27 hours, at 52th passage (10.5794/jjoms.36.307); 32-35 hours (lot 01212003), ~28 hours (lot 01262015) (JCRB).
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Val272Met (c.814G>A); ClinVar=VCV000185814; Zygosity=Unspecified (PubMed=9290701).
Disease Esophageal squamous cell carcinoma (NCIt: C4024)
Squamous cell carcinoma of the esophagus (ORDO: Orphanet_99977)
Derived from metastatic site: Bone; jaw; mandible.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_3174 ! T.T
Sex of cell Male
Age at sampling 67Y
Category Cancer cell line
STR profile Source(s): JCRB

Markers:
AmelogeninX,Y
CSF1PO11,13
D5S8188,10
D7S82011
D13S31710,11
D16S5399,11
TH019
TPOX8,11
vWA16,17

Run an STR similarity search on this cell line
Publications

DOI=10.5794/jjoms.36.307
Takahashi K., Kanazama H., Chan C.-T., Hosono T., Takahara M., Sato K.-I.
A case of esophageal carcinoma metastatic to the mandible and characterization of two cell lines (T-T and T-Tn) established from the oral tumor.
Nihon Koku Geka Gakkai Zasshi 36:307-316(1990)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=15885884; DOI=10.1016/j.canlet.2005.03.036
Lo P.H.-Y., Leung A.C.-C., Xiong W., Law S., Duh F.-M., Lerman M.I., Stanbridge E.J., Lung M.L.
Expression of candidate chromosome 3p21.3 tumor suppressor genes and down-regulation of BLU in some esophageal squamous cell carcinomas.
Cancer Lett. 234:184-192(2006)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

Cross-references
Cell line collections JCRB; JCRB0261
Cell line databases/resources LINCS_LDP; LCL-1562
Biological sample resources BioSample; SAMN03471669
Encyclopedic resources Wikidata; Q54971375
Gene expression databases GEO; GSM827521
GEO; GSM1374967
Polymorphism and mutation databases Cosmic; 873391
Cosmic; 923185
Cosmic; 1612902
IARC_TP53; 21668
Progenetix; CVCL_3175
Entry history
Entry creation04-Apr-2012
Last entry update16-Dec-2021
Version number22