ID   T.Tn
AC   CVCL_3175
SY   T_Tn; T-Tn; TTn; T Tn; T-Tn6; TTN
DR   CLO; CLO_0009936
DR   BioSample; SAMN03471669
DR   cancercelllines; CVCL_3175
DR   Cosmic; 873391
DR   Cosmic; 923185
DR   Cosmic; 1612902
DR   GEO; GSM827521
DR   GEO; GSM1374967
DR   IARC_TP53; 21668
DR   JCRB; JCRB0261
DR   LINCS_LDP; LCL-1562
DR   Progenetix; CVCL_3175
DR   Wikidata; Q54971375
RX   DOI=10.5794/jjoms.36.307;
RX   PubMed=9290701;
RX   PubMed=15885884;
RX   PubMed=20215515;
CC   Population: Japanese.
CC   Characteristics: Established from the original tumor through transplantation in nude mice.
CC   Doubling time: 27 hours (Note=At 52th passage) (DOI=10.5794/jjoms.36.307); 32-35 hours (Note=Lot 01212003), ~28 hours (Note=Lot 01262015) (JCRB=JCRB0261).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Val272Met (c.814G>A); ClinVar=VCV000185814; Zygosity=Unspecified (PubMed=9290701).
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: Metastatic; Bone, jaw, mandible; UBERON=UBERON_0001684.
ST   Source(s): JCRB
ST   Amelogenin: X,Y
ST   CSF1PO: 11,13
ST   D13S317: 10,11
ST   D16S539: 9,11
ST   D5S818: 8,10
ST   D7S820: 11
ST   TH01: 9
ST   TPOX: 8,11
ST   vWA: 16,17
DI   NCIt; C4024; Esophageal squamous cell carcinoma
DI   ORDO; Orphanet_99977; Squamous cell carcinoma of the esophagus
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_3174 ! T.T
SX   Male
AG   67Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 25
//
RX   DOI=10.5794/jjoms.36.307;
RA   Takahashi K., Kanazama H., Chan C.-T., Hosono T., Takahara M.,
RA   Sato K.-i.;
RT   "A case of esophageal carcinoma metastatic to the mandible and
RT   characterization of two cell lines (T-T and T-Tn) established from the
RT   oral tumor.";
RL   Nihon Koku Geka Gakkai Zasshi 36:307-316(1990).
//
RX   PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D;
RA   Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T.,
RA   Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M.,
RA   Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.;
RT   "Screening the p53 status of human cell lines using a yeast functional
RT   assay.";
RL   Mol. Carcinog. 19:243-253(1997).
//
RX   PubMed=15885884; DOI=10.1016/j.canlet.2005.03.036;
RA   Lo P.H.-Y., Leung A.C.-C., Xiong W.-J., Law S., Duh F.-M., Lerman M.I.,
RA   Stanbridge E.J., Lung M.L.;
RT   "Expression of candidate chromosome 3p21.3 tumor suppressor genes and
RT   down-regulation of BLU in some esophageal squamous cell carcinomas.";
RL   Cancer Lett. 234:184-192(2006).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458;
RA   Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P.,
RA   Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J.,
RA   Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C.,
RA   Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J.,
RA   Haber D.A.;
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//