Home  |  Contact

Cellosaurus TMH-1 (CVCL_3219)

[Text version]
Cell line name TMH-1
Accession CVCL_3219
Resource Identification Initiative To cite this cell line use: TMH-1 (RRID:CVCL_3219)
Comments Problematic cell line: Contaminated. Shown to be a IHH-4 derivative (PubMed=20143388). Originally thought to originate from a 79 year old female patient with a thyroid gland anaplastic carcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00349.
Population: Japanese.
Derived from site: Metastatic; Left cervical lymph node; UBERON=UBERON_0002429.
Sequence variations
  • Mutation; HGNC; 391; AKT1; Simple; p.Glu17Lys (c.49G>A); ClinVar=VCV000013983; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 2348; CREBBP; Simple; p.Trp592Ter (c.1776G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 14281; CRLF2; Simple; p.Trp255Ter (c.765G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 3373; EP300; Simple; p.Arg1312Ter (c.3934C>T); ClinVar=VCV000545969; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9801; RAC1; Simple; p.Asp11Glu (c.33C>G); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Heterozygous; Note=In promoter (from parent cell line).
Disease Thyroid gland papillary carcinoma (NCIt: C4035)
Differentiated thyroid carcinoma (ORDO: Orphanet_146)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2960 (IHH-4)
Sex of cell Male
Age at sampling 75Y
Category Cancer cell line
STR profile Source(s): JCRB

Markers:
AmelogeninX
CSF1PO12
D5S8189,13
D7S8209,10
D13S31710,13
D16S5399,11
TH019
TPOX11
vWA16,18

Run an STR similarity search on this cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx
Publications

PubMed=11686581; DOI=10.1016/S0753-3322(01)00087-7
Sekiguchi M., Shiroko Y., Arai T., Kishino T., Sugawara I., Kusakabe T., Suzuki T., Yamashita T., Obara T., Ito K., Hasumi K.
Biological characteristics and chemosensitivity profile of four human anaplastic thyroid carcinoma cell lines.
Biomed. Pharmacother. 55:466-474(2001)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cross-references
Cell line collections (Providers) JCRB; JCRB1078
JCRB; NIHS0267 - Discontinued
Cell line databases/resources cancercelllines; CVCL_3219
Cell_Model_Passport; SIDM00601
Biological sample resources BioSample; SAMN03151799
BioSample; SAMN03472499
Encyclopedic resources Wikidata; Q54972696
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number25