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Cellosaurus TYK-nu.CP-r (CVCL_3221)

[Text version]

Cell line name TYK-nu.CP-r
Synonyms TYK-nu (R); TYKNU CPR; TYK-nu-CisR; Tyk-nu-cisR; TYKnuCisR; TyknuCisR
Accession CVCL_3221
Secondary accession CVCL_EQ58
Resource Identification Initiative To cite this cell line use: TYK-nu.CP-r (RRID:CVCL_3221)
Comments Population: Japanese.
Selected for resistance to: ChEBI; CHEBI:27899; Cisplatin (CDDP).
Omics: Deep proteome analysis.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Heterozygous for NRAS p.Gly12Asp (c.35G>A) (ClinVar=VCV000039648) (from parent cell line).
Heterozygous for NRAS p.Gln61Lys (c.181C>A) (ClinVar=VCV000073058) (from parent cell line).
Homozygous for TP53 p.Arg175His (c.524G>A) (ClinVar=VCV000012374) (from parent cell line).
Disease High grade ovarian serous adenocarcinoma (NCIt: C105555)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1776 (TYK-nu)
Sex of cell Female
Age at sampling 38Y
Category Cancer cell line
STR profile Source(s): JCRB; PubMed=22710073


Run an STR similarity search on this cell line

Yoshiya N., Adachi S., Misawa Y., Yuzawa H., Honda T., Kanazawa K., Takeuchi S., Tanaka K., Tanaka K.
Isolation of cisplatin-resistant subline from human ovarian cancer cell line and analysis of its cell-biological characteristics.
Nihon Sanka Fujinka Gakkai Zasshi 41:7-14(1989)

PubMed=11330945; DOI=10.1006/gyno.2001.6132
Watanabe T., Imoto I., Kosugi Y., Ishiwata I., Inoue S., Takayama M., Sato A., Inazawa J.
A novel amplification at 17q21-23 in ovarian cancer cell lines detected by comparative genomic hybridization.
Gynecol. Oncol. 81:172-177(2001)

PubMed=12417041; DOI=10.1111/j.1349-7006.2002.tb01213.x
Watanabe T., Imoto I., Katahira T., Hirasawa A., Ishiwata I., Emi M., Takayama M., Sato A., Inazawa J.
Differentially regulated genes as putative targets of amplifications at 20q in ovarian cancers.
Jpn. J. Cancer Res. 93:1114-1122(2002)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=27561551; DOI=10.1038/ncomms12645
Coscia F., Watters K.M., Curtis M., Eckert M.A., Chiang C.Y., Tyanova S., Montag A., Lastra R.R., Lengyel E., Mann M.
Integrative proteomic profiling of ovarian cancer cell lines reveals precursor cell associated proteins and functional status.
Nat. Commun. 7:12645-12645(2016)

Cell line collections JCRB; JCRB0234.1
Cell line databases/resources CGH-DB; 383-2
CGH-DB; 9360-4
Ontologies EFO; EFO_0006767
Chemistry resources PharmacoDB; TYKnu_CPr_1615_2019
Gene expression databases ArrayExpress; E-MTAB-2706
GEO; GSM851947
Other Wikidata; Q54973462
Proteomic databases PRIDE; PXD003668
Entry history
Entry creation04-Apr-2012
Last entry update12-Jan-2021
Version number20