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Cellosaurus HCC1937 BL (CVCL_3281)

[Text version]
Cell line name HCC1937 BL
Synonyms HCC-1937BL; HCC1937-BL; HCC1937BL; Hamon Cancer Center 1937 BL
Accession CVCL_3281
Resource Identification Initiative To cite this cell line use: HCC1937 BL (RRID:CVCL_3281)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Caucasian.
Doubling time: ~48 hours (DSMZ=ACC-891).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Deep exome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by RNAseq.
Misspelling: HCC2337; PubMed=22032724; Note=Probably due to confusion with ATCC catalog number (CRL-2337).
Misspelling: HCC-2337; PubMed=25960936; Note=Probably due to confusion with ATCC catalog number (CRL-2337).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
  • Mutation; HGNC; 1100; BRCA1; Simple; p.Gln1756Profs*74 (c.5266dupC) (5382insC); ClinVar=VCV000017677; Zygosity=Heterozygous; Note=The breast carcinoma cell line HCC1937 (Cellosaurus=CVCL_0290) is homozygous for the same mutation (PubMed=9699648; PubMed=22032724).
HLA typing Source: PubMed=25960936
Class I
HLA-AA*23:01,24:02
HLA-BB*40:01,07:02
HLA-CC*03:04,07:02
Class II
HLA-DQDQA1*04:01,01:02
DQB1*06:02,04:02
HLA-DRDRB1*08:01,15:01
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_0290 ! HCC1937
Sex of cell Female
Age at sampling 24Y
Category Transformed cell line
STR profile Source(s): ATCC; DSMZ

Markers:
AmelogeninX
CSF1PO11,12
D2S133820,25
D3S135817,18
D5S81812
D7S8209,10
D8S117912,13
D13S31713 (ATCC)
13,14 (DSMZ)
D16S53913 (DSMZ)
13,14 (ATCC)
D18S5112,15
D19S43314,15
D21S1128,32.2
FGA20,22
Penta D9,11
Penta E7,13
TH016
TPOX8,11
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=9699648
Tomlinson G.E., Chen T.T.-L., Stastny V.A., Virmani A.K., Spillman M.A., Tonk V., Blum J.L., Schneider N.R., Wistuba I.I., Shay J.W., Minna J.D., Gazdar A.F.
Characterization of a breast cancer cell line derived from a germ-line BRCA1 mutation carrier.
Cancer Res. 58:3237-3242(1998)

PubMed=9833771; DOI=10.1002/(SICI)1097-0215(19981209)78:6<766::AID-IJC15>3.0.CO;2-L
Gazdar A.F., Kurvari V., Virmani A.K., Gollahon L., Sakaguchi M., Westerfield M., Kodagoda D.R., Stasny V., Cunningham H.T., Wistuba I.I., Tomlinson G.E., Tonk V., Ashfaq R., Leitch A.M., Minna J.D., Shay J.W.
Characterization of paired tumor and non-tumor cell lines established from patients with breast cancer.
Int. J. Cancer 78:766-774(1998)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=22032724; DOI=10.1186/1755-8794-4-75
Ha K.C.H., Lalonde E., Li L.-L., Cavallone L., Natrajan R., Lambros M.B., Mitsopoulos C., Hakas J., Kozarewa I., Fenwick K., Lord C.J., Ashworth A., Vincent-Salomon A., Basik M., Reis-Filho J.S., Majewski J., Foulkes W.D.
Identification of gene fusion transcripts by transcriptome sequencing in BRCA1-mutated breast cancers and cell lines.
BMC Med. Genomics 4:75.1-75.13(2011)

PubMed=25960936; DOI=10.4161/21624011.2014.954893
Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:e954893.1-e954893.12(2014)

Cross-references
Cell line collections (Providers) ATCC; CRL-2337
DSMZ; ACC-891
KCLB; 9S1937BL
Cell line databases/resources CLO; CLO_0003646
Cell_Model_Passport; SIDM00873
DepMap; ACH-002375
DSMZCellDive; ACC-891
Biological sample resources BioSample; SAMN03471821
Encyclopedic resources Wikidata; Q28872486
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number26