Cellosaurus Farage (CVCL_3302)

Cell line name Farage
Synonyms FARAGE; Farage OL; Farage Original Line
Accession CVCL_3302
Resource Identification Initiative To cite this cell line use: Farage (RRID:CVCL_3302)
Comments Part of: MD Anderson Cell Lines Project.
Microsatellite instability: Instable (MSI-low) (Sanger).
Omics: Array-based CGH.
Omics: CNV analysis.
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: miRNA expression profiling.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Diffuse large B-cell lymphoma (NCIt: C8851)
Derived from metastatic site: Lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children: CVCL_J602 (Farage 10.6.1)
Sex of cell Female
Category Cancer cell line
STR profile Source(s): ATCC; Cosmic-CLP

Markers:
AmelogeninX
CSF1PO11,12
D13S31711,13
D16S53911,12
D5S81812
D7S82012
TH018,9
TPOX9
vWA14,15
Web pages http://tcpaportal.org/mclp/
Publications

DOI=10.3109/10428199209053591
Ben-Bassat H., Polliack A., Shlomai Z., Kohn G., Hadar R., Rabinowitz R., Leizerowitz R., Matutes E., Buchier V., Brok-Simoni F., Okon E., Livni N., Schlesinger M.
Farage, a novel early B cell lymphoma cell line with trisomy 11.
Leuk. Lymphoma 6:513-521(1992)

PubMed=9172815; DOI=10.3109/10428199609093448
Baruch M., Hochberg M., Gabay C., Ben-Bassat H., Shlomai Z., Laskov R.
Molecular characterization of an unusual non-Hodgkin's B-lymphoma cell line ('Farage') lacking the ability to produce immunoglobulin polypeptide chains.
Leuk. Lymphoma 21:485-495(1996)

PubMed=11378582; DOI=10.3109/10428190109060355
Rabinowitz R., Yu Y., Belov E., Shubinsky G., Ben-Bassat H., Schlesinger M.
Regulation of the expression of CD45 isoforms in the Farage human B cell lymphoma line and its 10.6.1 subline.
Leuk. Lymphoma 41:643-654(2001)

PubMed=19278952; DOI=10.1182/blood-2009-01-202028
Li C., Kim S.-W., Rai D., Bolla A.R., Adhvaryu S., Kinney M.C., Robetorye R.S., Aguiar R.C.T.
Copy number abnormalities, MYC activity, and the genetic fingerprint of normal B cells mechanistically define the microRNA profile of diffuse large B-cell lymphoma.
Blood 113:6681-6690(2009)

PubMed=19358282; DOI=10.1002/ijc.24351
Inagaki A., Ishida T., Yano H., Ishii T., Kusumoto S., Ito A., Ri M., Mori F., Ding J., Komatsu H., Iida S., Ueda R.
Expression of the ULBP ligands for NKG2D by B-NHL cells plays an important role in determining their susceptibility to rituximab-induced ADCC.
Int. J. Cancer 125:212-221(2009)

PubMed=23292937; DOI=10.1073/pnas.1205299110
Zhang J., Grubor V., Love C.L., Banerjee A., Richards K.L., Mieczkowski P.A., Dunphy C., Choi W., Au W.Y., Srivastava G., Lugar P.L., Rizzieri D.A., Lagoo A.S., Bernal-Mizrachi L., Mann K.P., Flowers C., Naresh K., Evens A., Gordon L.I., Czader M., Gill J.I., Hsi E.D., Liu Q., Fan A., Walsh K., Jima D., Smith L.L., Johnson A.J., Byrd J.C., Luftig M.A., Ni T., Zhu J., Chadburn A., Levy S., Dunson D., Dave S.S.
Genetic heterogeneity of diffuse large B-cell lymphoma.
Proc. Natl. Acad. Sci. U.S.A. 110:1398-1403(2013)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references
Cell line collections ATCC; CRL-2630
Cell line databases/resources Cosmic-CLP; 1297449
GDSC; 1297449
IGRhCellID; Farage
LINCS_LDP; LCL-1131
Ontologies CLO; CLO_0002997
EFO; EFO_0006393
Biological sample resources BioSample; SAMN03471757
Gene expression databases GEO; GSM380125
GEO; GSM552429
GEO; GSM907525
GEO; GSM1374481
GEO; GSM1669792
Polymorphism and mutation databases Cosmic; 1295510
Cosmic; 1517602
Cosmic; 1541919
Cosmic; 1945180
Cosmic; 2022591
Cosmic; 2276315