Cellosaurus Farage (CVCL_3302)

Cell line name Farage
Synonyms FARAGE; Farage OL; Farage Original Line
Accession CVCL_3302
Resource Identification Initiative To cite this cell line use: Farage (RRID:CVCL_3302)
Comments Part of: COSMIC cell lines project.
Part of: MD Anderson Cell Lines Project.
Doubling time: 48 hours (DOI=10.3109/10428199209053591).
Microsatellite instability: Instable (MSI-low) (Sanger).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Array-based CGH.
Omics: CNV analysis.
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: miRNA expression profiling.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Lymph node.
Disease Diffuse large B-cell lymphoma germinal center B-Cell type (NCIt: C36080)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_J602 (Farage 10.6.1)
Sex of cell Female
Age at sampling 70Y
Category Cancer cell line
STR profile Source(s): ATCC; Cosmic-CLP

Markers:
AmelogeninX
CSF1PO11,12
D13S31711,13
D16S53911,12
D5S81812
D7S82012
TH018,9
TPOX9
vWA14,15
Web pages http://tcpaportal.org/mclp/
Publications

DOI=10.3109/10428199209053591
Ben-Bassat H., Polliack A., Shlomai Z., Kohn G., Hadar R., Rabinowitz R., Leizerowitz R., Matutes E., Buchier V., Brok-Simoni F., Okon E., Livni N., Schlesinger M.
Farage, a novel early B cell lymphoma cell line with trisomy 11.
Leuk. Lymphoma 6:513-521(1992)

PubMed=9172815; DOI=10.3109/10428199609093448
Baruch M., Hochberg M., Gabay C., Ben-Bassat H., Shlomai Z., Laskov R.
Molecular characterization of an unusual non-Hodgkin's B-lymphoma cell line ('Farage') lacking the ability to produce immunoglobulin polypeptide chains.
Leuk. Lymphoma 21:485-495(1996)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=11378582; DOI=10.3109/10428190109060355
Rabinowitz R., Yu Y., Belov E., Shubinsky G., Ben-Bassat H., Schlesinger M.
Regulation of the expression of CD45 isoforms in the Farage human B cell lymphoma line and its 10.6.1 subline.
Leuk. Lymphoma 41:643-654(2001)

PubMed=19278952; DOI=10.1182/blood-2009-01-202028
Li C., Kim S.-W., Rai D., Bolla A.R., Adhvaryu S., Kinney M.C., Robetorye R.S., Aguiar R.C.T.
Copy number abnormalities, MYC activity, and the genetic fingerprint of normal B cells mechanistically define the microRNA profile of diffuse large B-cell lymphoma.
Blood 113:6681-6690(2009)

PubMed=19358282; DOI=10.1002/ijc.24351
Inagaki A., Ishida T., Yano H., Ishii T., Kusumoto S., Ito A., Ri M., Mori F., Ding J., Komatsu H., Iida S., Ueda R.
Expression of the ULBP ligands for NKG2D by B-NHL cells plays an important role in determining their susceptibility to rituximab-induced ADCC.
Int. J. Cancer 125:212-221(2009)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=23292937; DOI=10.1073/pnas.1205299110
Zhang J., Grubor V., Love C.L., Banerjee A., Richards K.L., Mieczkowski P.A., Dunphy C., Choi W., Au W.Y., Srivastava G., Lugar P.L., Rizzieri D.A., Lagoo A.S., Bernal-Mizrachi L., Mann K.P., Flowers C., Naresh K., Evens A., Gordon L.I., Czader M., Gill J.I., Hsi E.D., Liu Q., Fan A., Walsh K., Jima D., Smith L.L., Johnson A.J., Byrd J.C., Luftig M.A., Ni T., Zhu J., Chadburn A., Levy S., Dunson D., Dave S.S.
Genetic heterogeneity of diffuse large B-cell lymphoma.
Proc. Natl. Acad. Sci. U.S.A. 110:1398-1403(2013)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references
Cell line collections ATCC; CRL-2630
Cell line databases/resources Cosmic-CLP; 1297449
GDSC; 1297449
IGRhCellID; Farage
LINCS_LDP; LCL-1131
Ontologies CLO; CLO_0002997
EFO; EFO_0006393
Biological sample resources BioSample; SAMN03471757
Gene expression databases ArrayExpress; E-MTAB-2706
GEO; GSM380125
GEO; GSM552429
GEO; GSM907525
GEO; GSM1035331
GEO; GSM1374481
GEO; GSM1669792
Polymorphism and mutation databases Cosmic; 1295510
Cosmic; 1517602
Cosmic; 1541919
Cosmic; 1945180
Cosmic; 2022591
Cosmic; 2276315