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Cellosaurus HMCB (CVCL_3317)

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Cell line name HMCB
Synonyms Human Melanoma Cell Bowes; Bowes melanoma cells; BOWES
Accession CVCL_3317
Resource Identification Initiative To cite this cell line use: HMCB (RRID:CVCL_3317)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Anecdotal: The Bowes cell line is famous for its use in the identification and purification of tissue-type plasminogen activator (tPA).
Caution: The exact relationship between HMCB (CVCL_3317) and RPMI-7262/7272/7932/7962/7972 is not clear: all are derived from patient 'Bowes' melanoma.
Sequence variations NRAS p.Gln61Lys (c.181C>A) (PubMed=12068308).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.21
Native American0
East Asian, North1.87
East Asian, South0
South Asian0
European, North63.92
European, South33.99
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_T313 ! RPMI-7262
CVCL_T314 ! RPMI-7272
CVCL_T315 ! RPMI-7551
CVCL_T316 ! RPMI-7781
CVCL_T317 ! RPMI-7801
CVCL_T318 ! RPMI-7922
CVCL_2713 ! RPMI-7932
CVCL_T319 ! RPMI-7962
CVCL_T320 ! RPMI-7972
CVCL_T321 ! RPMI-8002
CVCL_T322 ! RPMI-8072
Sex of cell Female
Category Cancer cell line
STR profile Source(s): ATCC

Markers:
AmelogeninX
CSF1PO10
D5S81811,12
D7S82011,13
D13S3178,11
D16S53913
TH019,9.3
TPOX8
vWA17

Run an STR similarity search on this cell line
Web pages http://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/b/cell-lines-detail-379.html
http://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/h/cell-lines-detail-109.html
Publications

PubMed=1970678; DOI=10.1007/BF02890069
Lombardi T., Castellucci M.
Bowes human melanoma cell line. An immunocytochemical study.
Virchows Arch. B. Cell. Pathol. Incl. Mol. Pathol. 58:181-183(1990)

Patent=US5010002
Levinson A., Simonsen C., Yelverton E.M.
Human t-PA production using vectors coding DHFR protein.
Patent number US5010002, 23-Apr-1991

PubMed=12068308; DOI=10.1038/nature00766
Davies H., Bignell G.R., Cox C., Stephens P., Edkins S., Clegg S., Teague J.W., Woffendin H., Garnett M.J., Bottomley W., Davis N., Dicks E., Ewing R., Floyd Y., Gray K., Hall S., Hawes R., Hughes J., Kosmidou V., Menzies A., Mould C., Parker A., Stevens C., Watt S., Hooper S., Wilson R., Jayatilake H., Gusterson B.A., Cooper C., Shipley J.M., Hargrave D., Pritchard-Jones K., Maitland N.J., Chenevix-Trench G., Riggins G.J., Bigner D.D., Palmieri G., Cossu A., Flanagan A.M., Nicholson A., Ho J.W.C., Leung S.Y., Yuen S.T., Weber B.L., Seigler H.F., Darrow T.L., Paterson H., Marais R., Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.
Mutations of the BRAF gene in human cancer.
Nature 417:949-954(2002)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections ATCC; CRL-9607
NCBI_Iran; C524
Cell line databases/resources CCLE; HMCB_SKIN
Cell_Model_Passport; SIDM00914
DepMap; ACH-000931
IGRhCellID; HMCB
Ontologies BTO; BTO:0001998
CLO; CLO_0003785
EFO; EFO_0002195
Biological sample resources BioSample; SAMN10988240
eagle-i; dartmouth.eagle-i.net/i/0000013e-d725-c97d-6a92-b95280000000
Chemistry resources ChEMBL-Cells; CHEMBL3308385
ChEMBL-Targets; CHEMBL614824
PharmacoDB; HMCB_553_2019
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM827473
GEO; GSM887087
GEO; GSM888157
Other Wikidata; Q54889913
Polymorphism and mutation databases Cosmic; 724822
LiGeA; CCLE_295
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number27