Cellosaurus HMCB (CVCL_3317)

Cell line name HMCB
Synonyms Human Melanoma Cell Bowes; Bowes melanoma cells
Accession CVCL_3317
Resource Identification Initiative To cite this cell line use: HMCB (RRID:CVCL_3317)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Anecdotal: The Bowes cell line is famous for its use in the identification and purification of tissue-type plasminogen activator (tPA).
Caution: The exact relationship between HMCB (CVCL_3317) and RPMI-7262/7272/7932/7962/7972 is not clear: all are derived from patient 'Bowes' melanoma.
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_T313 ! RPMI-7262
CVCL_T314 ! RPMI-7272
CVCL_T315 ! RPMI-7551
CVCL_T316 ! RPMI-7781
CVCL_T317 ! RPMI-7801
CVCL_T318 ! RPMI-7922
CVCL_2713 ! RPMI-7932
CVCL_T319 ! RPMI-7962
CVCL_T320 ! RPMI-7972
CVCL_T321 ! RPMI-8002
CVCL_T322 ! RPMI-8072
Sex of cell Female
Category Cancer cell line
STR profile Source(s): ATCC

Markers:
AmelogeninX
CSF1PO10
D13S3178,11
D16S53913
D5S81811,12
D7S82011,13
TH019,9.3
TPOX8
vWA17
Web pages http://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/b/cell-lines-detail-379.html
http://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/h/cell-lines-detail-109.html
Publications

PubMed=1970678; DOI=10.1007/BF02890069
Lombardi T., Castellucci M.
Bowes human melanoma cell line. An immunocytochemical study.
Virchows Arch. B. Cell. Pathol. Incl. Mol. Pathol. 58:181-183(1990)

Patent=US5010002
Levinson A., Simonsen C., Yelverton E.M.
Human t-PA production using vectors coding DHFR protein.
Patent number US5010002, 23-Apr-1991

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

Cross-references
Cell line collections ATCC; CRL-9607
NCBI_Iran; C524
Cell line databases/resources CCLE; HMCB_SKIN
IGRhCellID; HMCB
Ontologies BTO; BTO:0001998
CLO; CLO_0003785
EFO; EFO_0002195
Chemistry resources ChEMBL-Cells; CHEMBL3308385
ChEMBL-Targets; CHEMBL614824
Gene expression databases GEO; GSM827473
GEO; GSM887087
GEO; GSM888157
Polymorphism and mutation databases Cosmic; 724822