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Cellosaurus BGC-823 (CVCL_3360)

[Text version]

Cell line name BGC-823
Synonyms BGC823
Accession CVCL_3360
Resource Identification Initiative To cite this cell line use: BGC-823 (RRID:CVCL_3360)
Comments Problematic cell line: Contaminated. Shown to be a HeLa derivative (CCRID; PubMed=26116706; PubMed=28851942). Originally thought to be a gastric adenocarcinoma.
Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00570.
Population: African American.
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Omics: Proteome analysis by 2D-DE.
Omics: Transcriptome analysis.
Derived from sampling site: Uterus; cervix.
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0.77
East Asian, North2.9
East Asian, South0
South Asian0
European, North16.38
European, South13.96
Disease Human papillomavirus-related endocervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0030 (HeLa)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
STR profile Source(s): CCRID; PubMed=26116706; PubMed=28851942; PubMed=29717028

D19S43313 (CCRID; PubMed=28851942; PubMed=29717028)
13,14 (PubMed=26116706)
FGA21 (CCRID; PubMed=26116706; PubMed=28851942)
21,24 (PubMed=29717028)
Penta D8,15
Penta E7,17

Run an STR similarity search on this cell line
Web pages http://iclac.org/wp-content/uploads/Cross-Contaminations_v10_distribution.xlsx

PubMed=16344271; DOI=10.1093/carcin/bgi306
Li N., Guo R.-F., Li W.-M., Shao J.-M., Li S.-T., Zhao K., Chen X.-S., Xu N.-Z., Liu S.-Q., Lu Y.-Y.
A proteomic investigation into a human gastric cancer cell line BGC823 treated with diallyl trisulfide.
Carcinogenesis 27:1222-1231(2006)

PubMed=26116706; DOI=10.1096/fj.14-266718
Ye F., Chen C.-G., Qin J., Liu J., Zheng C.-Y.
Genetic profiling reveals an alarming rate of cross-contamination among human cell lines used in China.
FASEB J. 29:4268-4272(2015)

PubMed=28851942; DOI=10.1038/s41598-017-09660-w
Bian X.-C., Yang Z.-L., Feng H.-L., Sun H., Liu Y.-Q.
A combination of species identification and STR profiling identifies cross-contaminated cells from 482 human tumor cell lines.
Sci. Rep. 7:9774-9774(2017)

PubMed=29717028; DOI=10.1042/BSR20180277
Zhang Y.-Q., Yu S., Zhang Z.-Z., Zhao G., Xu J.
Long non-coding RNA AK096174 promotes cell proliferation and invasion in gastric cancer by regulating WDR66 expression.
Biosci. Rep. 38:BSR20180277.1-BSR20180277.12(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cell line collections CCTCC; GDC0151
ICLC; HTL98007 - Discontinued
Cell line databases/resources CCLE; BGC823_STOMACH
CCRID; 3111C0001CCC000062
CCRID; 3131C0001000700011
DepMap; ACH-001017
Ontologies BTO; BTO:0003878
CLO; CLO_0001952
Chemistry resources ChEMBL-Cells; CHEMBL3307635
ChEMBL-Targets; CHEMBL614526
PharmacoDB; BGC823_90_2019
Gene expression databases GEO; GSM828793
GEO; GSM843444
GEO; GSM1374404
Other Wikidata; Q54796238
Polymorphism and mutation databases Cosmic; 2267322
IARC_TP53; 24859
Entry history
Entry creation04-Apr-2012
Last entry update20-May-2021
Version number20