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Cellosaurus GLC-82 (CVCL_3371)

[Text version]

Cell line name GLC-82
Synonyms Glc-82; GLC82; Gejiu Lung Carcinoma-82
Accession CVCL_3371
Resource Identification Initiative To cite this cell line use: GLC-82 (RRID:CVCL_3371)
Comments Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=26116706). Originally thought to originate from a 32 year old female patient with a lung adenocarcinoma.
Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: 48 hours (PubMed=4006684).
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Genome ancestry Source: PubMed=30894373

Origin% genome
African66.32
Native American1.23
East Asian, North2.62
East Asian, South0
South Asian0
European, North15.73
European, South14.1
Disease Human papillomavirus-related endocervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0030 (HeLa)
Children:
CVCL_6906 (HAC-84)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
STR profile Source(s): CCRID; PubMed=26116706

Markers:
AmelogeninX
CSF1PO9,10
D2S133817
D3S135818
D5S81811,12
D6S104318,19
D7S8208,12
D8S117912,13
D12S39120,25
D13S31712,13.3
D16S5399,10
D18S5116
D19S43313,14
D21S1127,28
FGA21
Penta D8,15
Penta E7,17
TH017
TPOX8,12
vWA16,18

Run an STR similarity search on this cell line
Web pages http://www.cellresource.cn/fdetail.aspx?id=67
Publications

PubMed=4006684
Liang M.-D., Jia W., Hu M.-Y., Wang Z.-X., Liu G.-Y., Zhou K.-M.
Establishment of lung adenocarcinoma cell line in Gejiu (GLC-82) and study of its biologic properties.
Zhonghua Zhong Liu Za Zhi 7:81-82(1985)

PubMed=2838234
Liang M.-D., Hu M.-Y., Jia W., Wang Z.-X., Mong F.-H., Zhou K.-M.
Establishment of a human lung alveolar cancer cell strain and its characteristics.
Zhonghua Zhong Liu Za Zhi 9:336-338(1987)

PubMed=3471311; DOI=10.1016/0165-4608(87)90066-5
Fan Y.-S., Li P.
Cytogenetic studies of four human lung adenocarcinoma cell lines.
Cancer Genet. Cytogenet. 26:317-325(1987)

PubMed=20545000; DOI=10.3724/SP.J.1141.2010.02113
Peng K.-J., Wang J.-H., Su W.-T., Wang X.-C., Yang F.-T., Nie W.-H.
Characterization of two human lung adenocarcinoma cell lines by reciprocal chromosome painting.
Dong Wu Xue Yan Jiu 31:113-121(2010)

PubMed=25433501; DOI=10.1007/s13277-014-2888-7
Miao Z.-F., Li W.-Y., Wang Z.-N., Zhao T.-T., Xu Y.-Y., Song Y.-X., Huang J.-Y., Xu H.-M.
Lung cancer cells induce senescence and apoptosis of pleural mesothelial cells via transforming growth factor-beta1.
Tumor Biol. 36:2657-2665(2015)

PubMed=26116706; DOI=10.1096/fj.14-266718
Ye F., Chen C.-G., Qin J., Liu J., Zheng C.-Y.
Genetic profiling reveals an alarming rate of cross-contamination among human cell lines used in China.
FASEB J. 29:4268-4272(2015)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections ICLC; HTL98006 - Discontinued
KCB; KCB 86017YJ
KCB; KCB 200435YJ
Cell line databases/resources CCLE; GLC82_LUNG
CCRID; 3111C0001CCC000067
DepMap; ACH-001071
TOKU-E; 3607
Ontologies BTO; BTO:0004113
CLO; CLO_0003505
Chemistry resources PharmacoDB; GLC82_406_2019
Other Wikidata; Q54835925
Polymorphism and mutation databases Cosmic; 753557
Entry history
Entry creation04-Apr-2012
Last entry updated19-Dec-2019
Version number18