Cellosaurus NT2-D1 (CVCL_3407)

Cell line name NT2-D1
Synonyms NT2/D1; NT2D1; Nt2D1; NTERA-2 clone D1; NTERA2-cloneD1; NTERA-2 cl.D1; NTera2 cl.D1; NTERA-2cl.D1; NTera 2/cl.D1; NTERA-2/D1; NTera2/D1; Ntera2/D1; NTERA2-D1; NTera-2D1; NTERA2/D1; NTERA2D1; NTera2D1
Accession CVCL_3407
Resource Identification Initiative To cite this cell line use: NT2-D1 (RRID:CVCL_3407)
Comments Part of: ENCODE project common cell types; tier 3.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: H3K9ac ChIP-seq epigenome analysis.
Misspelling: NTERA-S-cl-D1; In Cosmic 1995598.
Misspelling: NTL-D1; In Cosmic 2077191.
Misspelling: NT2101; In PubMed=24812411 and Cosmic 2163756.
Disease Embryonal carcinoma (NCIt: C3752)
Derived from metastatic site: Lung.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0034 (NTERA-2)
Children: CVCL_7929 (NT2-N)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): ATCC; Cosmic-CLP; ECACC

Markers:
AmelogeninX,Y
CSF1PO10,12
D13S31713
D16S53911,12,13
D5S8189,12
D7S82010,12
TH019.3
TPOX8
vWA18,19
Web pages https://en.wikipedia.org/wiki/NTERA-2
http://genome.ucsc.edu/ENCODE/protocols/cell/human/NT2-D1_protocol.pdf
http://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/n/cell-lines-detail-113.html
Publications

PubMed=6144603; DOI=10.1016/0012-1606(84)90316-6
Andrews P.W.
Retinoic acid induces neuronal differentiation of a cloned human embryonal carcinoma cell line in vitro.
Dev. Biol. 103:285-293(1984)

PubMed=6694356
Andrews P.W., Damjanov I., Simon D., Banting G.S., Carlin C., Dracopoli N.C., Fogh J.
Pluripotent embryonal carcinoma clones derived from the human teratocarcinoma cell line Tera-2. Differentiation in vivo and in vitro.
Lab. Invest. 50:147-162(1984)

PubMed=3293662; DOI=10.1016/0304-419X(88)90003-0
Andrews P.W.
Human teratocarcinomas.
Biochim. Biophys. Acta 948:17-36(1988)

PubMed=8411264; DOI=10.1002/jnr.490350603
Pleasure S.J., Lee V.M.-Y.
NTera 2 cells: a human cell line which displays characteristics expected of a human committed neuronal progenitor cell.
J. Neurosci. Res. 35:585-602(1993)

PubMed=23325432; DOI=10.1101/gr.147942.112
Varley K.E., Gertz J., Bowling K.M., Parker S.L., Reddy T.E., Pauli-Behn F., Cross M.K., Williams B.A., Stamatoyannopoulos J.A., Crawford G.E., Absher D.M., Wold B.J., Myers R.M.
Dynamic DNA methylation across diverse human cell lines and tissues.
Genome Res. 23:555-567(2013)

PubMed=24812411; DOI=10.1158/1078-0432.CCR-13-2868
Feldman D.R., Iyer G., Van Alstine L., Patil S., Al-Ahmadie H., Reuter V.E., Bosl G.J., Chaganti R.S.K., Solit D.B.
Presence of somatic mutations within PIK3CA, AKT, RAS, and FGFR3 but not BRAF in cisplatin-resistant germ cell tumors.
Clin. Cancer Res. 20:3712-3720(2014)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections ATCC; CRL-1973
BCRC; 60356
BCRJ; 0303
ECACC; 01071221
ICLC; HTL97025
IZSLER; BS TCL 204
Cell line databases/resources CLDB; cl3740
CLDB; cl5088
Cosmic-CLP; 908454
GDSC; 908454
LINCS_LDP; LCL-1901
Ontologies BTO; BTO:0000946
CLO; CLO_0008207
EFO; EFO_0005236
Biological sample resources ENCODE; ENCBS374ENC
ENCODE; ENCBS578HFO
ENCODE; ENCBS631LTU
ENCODE; ENCBS810EWQ
Chemistry resources ChEMBL-Cells; CHEMBL3307482
ChEMBL-Targets; CHEMBL614206
Gene expression databases GEO; GSM824855
GEO; GSM824856
GEO; GSM1040297
GEO; GSM1040367
GEO; GSM1670285
Polymorphism and mutation databases Cosmic; 687052
Cosmic; 908454
Cosmic; 1995598
Cosmic; 2077191
Cosmic; 2163756