ID   Lec1
AC   CVCL_3440
SY   CHO-Lec1; CHO Lec1; Pro-Lec1.3C; Pro-5 Lec1.3c; Pro-5WgaRI3C
DR   CLO; CLO_0007301
DR   ATCC; CRL-1735
DR   CCRID; 3131C0001000100008
DR   Wikidata; Q54902418
RX   PubMed=1182798;
RX   PubMed=3785164;
RX   PubMed=8910379;
RX   PubMed=24078077;
CC   Sequence variation: Mgat1 p.Cys123Arg, p.Gln339Arg and p.Lys401Arg. Mgat1 p.Cys123Arg abolishes the activity of the enzyme (PubMed=8910379).
CC   Derived from sampling site: Ovary.
OX   NCBI_TaxID=10029; ! Cricetulus griseus
HI   CVCL_4382 ! CHO Pro-5
SX   Female
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 04-04-12; Last updated: 12-03-20; Version: 12
RX   PubMed=1182798; DOI=10.1016/0092-8674(75)90002-1;
RA   Stanley P., Caillibot V., Siminovitch L.;
RT   "Selection and characterization of eight phenotypically distinct lines
RT   of lectin-resistant Chinese hamster ovary cell.";
RL   Cell 6:121-128(1975).
RX   PubMed=3785164; DOI=10.1128/MCB.6.4.1268;
RA   Ripka J., Shin S.-I., Stanley P.;
RT   "Decreased tumorigenicity correlates with expression of altered cell
RT   surface carbohydrates in Lec9 CHO cells.";
RL   Mol. Cell. Biol. 6:1268-1275(1986).
RX   PubMed=8910379; DOI=10.1074/jbc.271.44.27818;
RA   Puthalakath H., Burke J., Gleeson P.A.;
RT   "Glycosylation defect in Lec1 Chinese hamster ovary mutant is due to a
RT   point mutation in N-acetylglucosaminyltransferase I gene.";
RL   J. Biol. Chem. 271:27818-27822(1996).
RX   PubMed=24078077; DOI=10.1007/s00418-013-1146-1;
RA   Dong Z., Zuber C., Pierce M., Stanley P., Roth J.;
RT   "Reduction in Golgi apparatus dimension in the absence of a
RT   residential protein, N-acetylglucosaminyltransferase V.";
RL   Histochem. Cell Biol. 141:153-164(2014).