ID   CEM/C1
AC   CVCL_3496
SY   CCRF-CEM C1; CEM-C1; CEM.C1; CEMC1
DR   BTO; BTO:0000225
DR   CLO; CLO_0002355
DR   EFO; EFO_0001667
DR   ArrayExpress; E-MTAB-38
DR   ATCC; CRL-2265
DR   BioSample; SAMN03471854
DR   cancercelllines; CVCL_3496
DR   CCRID; 3101HUMTCHu212
DR   Cell_Model_Passport; SIDM01256
DR   CLS; 305103
DR   Cosmic; 724837
DR   IGRhCellID; CEMC1
DR   IZSLER; BS TCL 160
DR   LINCS_LDP; LCL-1034
DR   Lonza; 241
DR   Progenetix; CVCL_3496
DR   Wikidata; Q54809269
RX   PubMed=7579731;
RX   PubMed=8895760;
RX   PubMed=12068308;
RX   PubMed=20215515;
CC   Population: Caucasian.
CC   Doubling time: ~26 hours (ATCC=CRL-2265).
CC   Selected for resistance to: ChEBI; CHEBI:27656; Camptothecin (CPT).
CC   Sequence variation: Gene fusion; HGNC; 13222; BCL11B + HGNC; 2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (PubMed=12068308).
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
CC   Omics: SNP array analysis.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
ST   Source(s): ATCC; IZSLER
ST   Amelogenin: X
ST   CSF1PO: 11
ST   D13S317: 9,10,12 (ATCC)
ST   D13S317: 10,12 (IZSLER)
ST   D16S539: 10,13
ST   D21S11: 30,33.2,34.2
ST   D5S818: 12,13
ST   D7S820: 9,12
ST   TH01: 6,7
ST   TPOX: 8
ST   vWA: 18,19
DI   NCIt; C7953; Childhood T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0207 ! CCRF-CEM
SX   Female
AG   3Y11M
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 36
//
RX   PubMed=7579731;
RA   Kapoor R., Slade D.L., Fujimori A., Pommier Y., Harker W.G.;
RT   "Altered topoisomerase I expression in two subclones of human CEM
RT   leukemia selected for resistance to camptothecin.";
RL   Oncol. Res. 7:83-95(1995).
//
RX   PubMed=8895760;
RA   Geley S., Hartmann B.L., Hala M., Strasser-Wozak E.M.C., Kapelari K.,
RA   Kofler R.;
RT   "Resistance to glucocorticoid-induced apoptosis in human T-cell acute
RT   lymphoblastic leukemia CEM-C1 cells is due to insufficient
RT   glucocorticoid receptor expression.";
RL   Cancer Res. 56:5033-5038(1996).
//
RX   PubMed=12068308; DOI=10.1038/nature00766;
RA   Davies H., Bignell G.R., Cox C., Stephens P.J., Edkins S., Clegg S.,
RA   Teague J.W., Woffendin H., Garnett M.J., Bottomley W., Davis N.,
RA   Dicks E., Ewing R., Floyd Y., Gray K., Hall S., Hawes R., Hughes J.,
RA   Kosmidou V., Menzies A., Mould C., Parker A., Stevens C., Watt S.,
RA   Hooper S., Wilson R., Jayatilake H., Gusterson B.A., Cooper C.S.,
RA   Shipley J.M., Hargrave D., Pritchard-Jones K., Maitland N.J.,
RA   Chenevix-Trench G., Riggins G.J., Bigner D.D., Palmieri G., Cossu A.,
RA   Flanagan A.M., Nicholson A., Ho J.W.C., Leung S.Y., Yuen S.T.,
RA   Weber B.L., Seigler H.F., Darrow T.L., Paterson H.F., Marais R.,
RA   Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.;
RT   "Mutations of the BRAF gene in human cancer.";
RL   Nature 417:949-954(2002).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458;
RA   Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P.,
RA   Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J.,
RA   Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C.,
RA   Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J.,
RA   Haber D.A.;
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//