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Cellosaurus CEM/C2 (CVCL_3497)

[Text version]

Cell line name CEM/C2
Synonyms CCRF-CEM C2; CEM-C2; CEMC2
Accession CVCL_3497
Resource Identification Initiative To cite this cell line use: CEM/C2 (RRID:CVCL_3497)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:27656; Camptothecin (CPT).
Derived from sampling site: Peripheral blood. Cell type=T-cell.
Sequence variations
  • Gene fusion; HGNC; 13222; BCL11B + HGNC; 2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
  • Mutation; HGNC; 16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (PubMed=12068308).
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0207 (CCRF-CEM)
Sex of cell Female
Age at sampling 3Y11M
Category Cancer cell line
STR profile Source(s): ATCC

Markers:
AmelogeninX
CSF1PO11
D5S81813
D7S8208.3,9
D13S31711,12
D16S53910,13
TH016,7
TPOX8
vWA17,19

Run an STR similarity search on this cell line
Publications

PubMed=7579731
Kapoor R., Slade D.L., Fujimori A., Pommier Y., Harker W.G.
Altered topoisomerase I expression in two subclones of human CEM leukemia selected for resistance to camptothecin.
Oncol. Res. 7:83-95(1995)

PubMed=12068308; DOI=10.1038/nature00766
Davies H., Bignell G.R., Cox C., Stephens P.J., Edkins S., Clegg S., Teague J.W., Woffendin H., Garnett M.J., Bottomley W., Davis N., Dicks E., Ewing R., Floyd Y., Gray K., Hall S., Hawes R., Hughes J., Kosmidou V., Menzies A., Mould C., Parker A., Stevens C., Watt S., Hooper S., Wilson R., Jayatilake H., Gusterson B.A., Cooper C., Shipley J.M., Hargrave D., Pritchard-Jones K., Maitland N.J., Chenevix-Trench G., Riggins G.J., Bigner D.D., Palmieri G., Cossu A., Flanagan A.M., Nicholson A., Ho J.W.C., Leung S.Y., Yuen S.T., Weber B.L., Seigler H.F., Darrow T.L., Paterson H.F., Marais R., Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.
Mutations of the BRAF gene in human cancer.
Nature 417:949-954(2002)

Cross-references
Cell line collections ATCC; CRL-2264
IZSLER; BS TCL 153
Cell line databases/resources CLO; CLO_0002356
CLDB; cl5178
Cell_Model_Passport; SIDM01250
LINCS_LDP; LCL-1035
Anatomy/cell type resources BTO; BTO:0005931
Biological sample resources BioSample; SAMN03471853
Chemistry resources ChEMBL-Cells; CHEMBL3307952
ChEMBL-Targets; CHEMBL612406
Encyclopedic resources Wikidata; Q54809270
Polymorphism and mutation databases Cosmic; 683535
Entry history
Entry creation04-Apr-2012
Last entry update23-Jun-2022
Version number27