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Cellosaurus H69AR (CVCL_3513)

Cell line name H69AR
Synonyms H-69AR
Accession CVCL_3513
Resource Identification Initiative To cite this cell line use: H69AR (RRID:CVCL_3513)
Comments Part of: MD Anderson Cell Lines Project.
Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Disease Small cell lung carcinoma (NCIt: C4917)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1579 (NCI-H69)
CVCL_4T78 (H69PR)
Sex of cell Male
Age at sampling 55Y
Category Cancer cell line
STR profile Source(s): ATCC

Web pages http://tcpaportal.org/mclp/

Mirski S.E.L., Gerlach J.H., Cole S.P.C.
Multidrug resistance in a human small cell lung cancer cell line selected in adriamycin.
Cancer Res. 47:2594-2598(1987)

PubMed=1314068; DOI=10.1038/bjc.1992.103
Cole S.P.C., Pinkoski M.J., Bhardwaj G., Deeley R.G.
Elevated expression of annexin II (lipocortin II, p36) in a multidrug resistant small cell lung cancer cell line.
Br. J. Cancer 65:498-502(1992)

Deeley R.G., Cole S.P.C.
Multidrug resistance protein.
Patent number US5489519, 06-Feb-1996

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cell line collections ATCC; CRL-11351
Cell line databases/resources IGRhCellID; H69AR
Ontologies BTO; BTO:0005367
CLO; CLO_0003610
Gene expression databases GEO; GSM169453
GEO; GSM827497
GEO; GSM986176
Other Wikidata; Q54872205