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Cellosaurus H69AR (CVCL_3513)

[Text version]

Cell line name H69AR
Synonyms H-69AR; NCI-H69AR
Accession CVCL_3513
Resource Identification Initiative To cite this cell line use: H69AR (RRID:CVCL_3513)
Comments Part of: MD Anderson Cell Lines Project.
Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Heterozygous for PIK3CA p.Gly106_Arg108del (c.317_325dellGGCAACCGT) (from parent cell line).
Homozygous for RB1 p.Glu748Ter (c.2242G>T) (from parent cell line).
Homozygous for TP53 p.Glu171Ter (c.511G>T) (ClinVar=VCV000634771) (from parent cell line).
Disease Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1579 (NCI-H69)
Children:
CVCL_4T78 (H69PR)
Sex of cell Male
Age at sampling 55Y
Category Cancer cell line
STR profile Source(s): ATCC

Markers:
AmelogeninX
CSF1PO10,12
D5S81811,13
D7S8209
D13S31712
D16S53911
TH018,9
TPOX10
vWA16,17

Run an STR similarity search on this cell line
Web pages http://tcpaportal.org/mclp/
Publications

PubMed=2436751
Mirski S.E.L., Gerlach J.H., Cole S.P.C.
Multidrug resistance in a human small cell lung cancer cell line selected in adriamycin.
Cancer Res. 47:2594-2598(1987)

PubMed=1314068; DOI=10.1038/bjc.1992.103
Cole S.P.C., Pinkoski M.J., Bhardwaj G., Deeley R.G.
Elevated expression of annexin II (lipocortin II, p36) in a multidrug resistant small cell lung cancer cell line.
Br. J. Cancer 65:498-502(1992)

Patent=US5489519
Deeley R.G., Cole S.P.C.
Multidrug resistance protein.
Patent number US5489519, 06-Feb-1996

PubMed=17426248; DOI=10.1158/1541-7786.MCR-06-0367
Olejniczak E.T., Van Sant C., Anderson M.G., Wang G., Tahir S.K., Sauter G., Lesniewski R., Semizarov D.
Integrative genomic analysis of small-cell lung carcinoma reveals correlates of sensitivity to bcl-2 antagonists and uncovers novel chromosomal gains.
Mol. Cancer Res. 5:331-339(2007)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references
Cell line collections ATCC; CRL-11351
Cell line databases/resources IGRhCellID; H69AR
Ontologies BTO; BTO:0005367
CLO; CLO_0003610
Gene expression databases GEO; GSM169453
GEO; GSM170728
GEO; GSM827497
GEO; GSM986176
Other Wikidata; Q54872205
Entry history
Entry creation04-Apr-2012
Last entry update02-Jul-2020
Version number20