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Cellosaurus HuT 102 (CVCL_3526)

[Text version]

Cell line name HuT 102
Synonyms HUT 102; Hut 102; HuT-102; Hut-102; HUT-102; HuT102; Hut102; HUT102; NCI-H102
Accession CVCL_3526
Resource Identification Initiative To cite this cell line use: HuT 102 (RRID:CVCL_3526)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: Tumor Immunology Bank (TIB) collection from Salk (transferred to ATCC in 1981).
Doubling time: 38 hours (PubMed=6244013).
Transformant: NCBI_TaxID; 11908; Human T-lymphotropic virus 1 (HTLV-1).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Omics: Virome analysis using RNAseq.
Derived from sampling site: Lymph node.
HLA typing Source: IPD-IMGT/HLA; 10777
Class I
HLA-AA*66:02
Genome ancestry Source: PubMed=30894373

Origin% genome
African84.86
Native American0.23
East Asian, North1.93
East Asian, South0
South Asian0
European, North6.73
European, South6.25
Disease Mycosis fungoides and Sezary syndrome (NCIt: C9265)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_8329 (HuT 102B)
Sex of cell Male
Age at sampling 28Y
Category Cancer cell line
STR profile Source(s): ATCC; CCRID; PubMed=28357668

Markers:
AmelogeninX,Y
CSF1PO8,11
D2S133819,23
D3S135815,16
D5S8188,13
D6S104311,18
D7S8208,10
D8S117913,15
D12S39116,19
D13S31711,13
D16S53912
D18S5120
D19S43314
D21S1128,29
FGA24
Penta D8,10
Penta E7,8
TH017,8
TPOX6
vWA16,19

Run an STR similarity search on this cell line
Web pages http://www.bmj.com/rapid-response/2011/10/30/cell-lines-hut102-and-hut78
https://www.atcc.org/support/faqs/f6d80/HuT%20102%20ATCC%20TIB-162%20cell%20growth.aspx
http://www.cellresource.cn/fdetail.aspx?id=403
http://www.cellresource.cn/fdetail.aspx?id=819
http://www.cellresource.cn/fdetail.aspx?id=2141
Publications

PubMed=6244013
Gazdar A.F., Carney D.N., Bunn P.A. Jr., Russell E.K., Jaffe E.S., Schechter G.P., Guccion J.G.
Mitogen requirements for the in vitro propagation of cutaneous T-cell lymphomas.
Blood 55:409-417(1980)

PubMed=8127147
Heyman M., Grander D., Brondum-Nielsen K., Cederblad B., Liu Y., Xu B., Einhorn S.
Interferon system defects in malignant T-cells.
Leukemia 8:425-434(1994)

PubMed=7662981
Imada K., Takaori-Kondo A., Akagi T., Shimotohno K., Sugamura K., Hattori T., Yamabe H., Okuma M., Uchiyama T.
Tumorigenicity of human T-cell leukemia virus type I-infected cell lines in severe combined immunodeficient mice and characterization of the cells proliferating in vivo.
Blood 86:2350-2357(1995)

PubMed=8547074; DOI=10.1111/j.1365-2141.1995.tb05302.x
Siebert R., Willers C.P., Schramm A., Fossa A., Dresen I.M.G., Uppenkamp M., Nowrousian M.R., Seeber S., Opalka B.
Homozygous loss of the MTS1/p16 and MTS2/p15 genes in lymphoma and lymphoblastic leukaemia cell lines.
Br. J. Haematol. 91:350-354(1995)

PubMed=8641406; DOI=10.1111/j.1600-0609.1996.tb00721.x
Borgonovo Brandter L., Heyman M., Rasool O., Liu Y., Grander D., Einhorn S.
p16INK4/p15INK4B gene inactivation is a frequent event in malignant T-cell lines.
Eur. J. Haematol. 56:313-318(1996)

PubMed=8806089; DOI=10.1002/jcb.240630502
Gazdar A.F., Minna J.D.
NCI series of cell lines: an historical perspective.
J. Cell. Biochem. 63 Suppl. 24:1-11(1996)

PubMed=8806090; DOI=10.1002/jcb.240630503
Bunn P.A. Jr., Foss F.M.
T-cell lymphoma cell lines (HUT102 and HUT78) established at the National Cancer Institute: history and importance to understanding the biology, clinical features, and therapy of cutaneous T-cell lymphomas (CTCL) and adult T-cell leukemia-lymphomas (ATLL).
J. Cell. Biochem. 63 Suppl. 24:12-23(1996)

PubMed=8806092; DOI=10.1002/jcb.240630505
Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P., McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr., Carney D.N., Minna J.D., Mulshine J.L.
NCI-Navy Medical Oncology Branch cell line data base.
J. Cell. Biochem. 63 Suppl. 24:32-91(1996)

PubMed=9738977; DOI=10.1111/j.1349-7006.1998.tb03275.x
Takizawa J., Suzuki R., Kuroda H., Utsunomiya A., Kagami Y., Joh T., Aizawa Y., Ueda R., Seto M.
Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia.
Jpn. J. Cancer Res. 89:712-718(1998)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=15638862; DOI=10.1111/j.1365-2141.2004.05289.x
Hasegawa H., Yamada Y., Harasawa H., Tsuji T., Murata K., Sugahara K., Tsuruda K., Ikeda S., Imaizumi Y., Tomonaga M., Masuda M., Takasu N., Kamihira S.
Sensitivity of adult T-cell leukaemia lymphoma cells to tumour necrosis factor-related apoptosis-inducing ligand.
Br. J. Haematol. 128:253-265(2005)

PubMed=17170727; DOI=10.1038/sj.leu.2404486
Sandberg Y., Verhaaf B., van Gastel-Mol E.J., Wolvers-Tettero I.L.M., de Vos J., Macleod R.A.F., Noordzij J.G., Dik W.A., van Dongen J.J.M., Langerak A.W.
Human T-cell lines with well-defined T-cell receptor gene rearrangements as controls for the BIOMED-2 multiplex polymerase chain reaction tubes.
Leukemia 21:230-237(2007)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25355872; DOI=10.1128/JVI.02570-14
Cao S., Strong M.J., Wang X., Moss W.N., Concha M., Lin Z., O'Grady T., Baddoo M., Fewell C., Renne R., Flemington E.K.
High-throughput RNA sequencing-based virome analysis of 50 lymphoma cell lines from the Cancer Cell Line Encyclopedia project.
J. Virol. 89:713-729(2015)

PubMed=28357668; DOI=10.1007/978-1-4939-6872-5_11
Raimondi V., Minuzzo S., Ciminale V., D'Agostino D.M.
STR profiling of HTLV-1-infected cell lines.
Methods Mol. Biol. 1582:143-154(2017)

PubMed=30285677; DOI=10.1186/s12885-018-4840-5
Tan K.-T., Ding L.-W., Sun Q.-Y., Lao Z.-T., Chien W., Ren X., Xiao J.-F., Loh X.-Y., Xu L., Lill M., Mayakonda A., Lin D.-C., Yang H., Koeffler H.P.
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
BMC Cancer 18:940-940(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections ATCC; TIB-162 - Discontinued
CCTCC; GDC0051
KCLB; 90102 - Discontinued
RCB; RCB1979 - Discontinued
TKG; TKG 0382
Cell line databases/resources CLDB; cl1776
CCLE; HUT102_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
CCRID; 3111C0001CCC000468
CCRID; 3111C0002000000031
CCRID; 3142C0001000000051
DepMap; ACH-000612
IPD-IMGT/HLA; 10777
Lonza; 99
Ontologies CLO; CLO_0004303
Biological sample resources BioSample; SAMN03471941
BioSample; SAMN10987657
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM887153
GEO; GSM888225
Other Wikidata; Q54896907
Polymorphism and mutation databases Cosmic; 850197
Cosmic; 933552
Cosmic; 2361371
LiGeA; CCLE_120
Entry history
Entry creation04-Apr-2012
Last entry updated05-Jul-2019
Version number22