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Cellosaurus RIN-14B (CVCL_3583)

[Text version]
Cell line name RIN-14B
Synonyms Rin-14B; RIN14B; Rin14B; RIN-m 14B; RIN-m clone 14B; 14B
Accession CVCL_3583
Resource Identification Initiative To cite this cell line use: RIN-14B (RRID:CVCL_3583)
Comments Characteristics: Produces somatostatin and aromatic-L-amino-acid decarboxylase (DDC). Secretes insulin but at lower level than the parent cell line (PubMed=6141566; PubMed=6295859).
Transformant: NCIt; C17262; X-Ray.
Derived from site: In situ; Pancreas, islets of Langerhans; UBERON=UBERON_0000006.
Cell type: Pancreatic delta cell; CL=CL_0000173.
Disease Rat insulinoma (NCIt: C121566)
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: NEDH.
Hierarchy Parent: CVCL_3584 (RIN-m)
Sex of cell Male
Age at sampling 666D
Category Cancer cell line
Publications

PubMed=6295859; DOI=10.2337/diab.31.6.521
Bhathena S.J., Oie H.K., Gazdar A.F., Voyles N.R., Wilkins S.D., Recant L.
Insulin, glucagon, and somatostatin receptors on cultured cells and clones from rat islet cell tumor.
Diabetes 31:521-531(1982)

PubMed=6141566; DOI=10.3181/00379727-175-41762
Bhathena S.J., Awoke S., Voyles N.R., Wilkins S.D., Recant L., Oie H.K., Gazdar A.F.
Insulin, glucagon, and somatostatin secretion by cultured rat islet cell tumor and its clones.
Proc. Soc. Exp. Biol. Med. 175:35-38(1984)

PubMed=1847683; DOI=10.1111/j.1432-1033.1991.tb15726.x
Amiranoff B., Lorinet A.-M., Laburthe M.
A clonal rat pancreatic delta cell line (Rin14B) expresses a high number of galanin receptors negatively coupled to a pertussis-toxin-sensitive cAMP-production pathway.
Eur. J. Biochem. 195:459-463(1991)

PubMed=9271225; DOI=10.1016/s0014-5793(97)00723-0
Branstrom R., Hoog A., Wahl M.A., Berggren P.-O., Larsson O.
RIN14B: a pancreatic delta-cell line that maintains functional ATP-dependent K+ channels and capability to secrete insulin under conditions where it no longer secretes somatostatin.
FEBS Lett. 411:301-307(1997)

Cross-references
Cell line collections (Providers) AddexBio; C0018020/5022
ATCC; CRL-2059
Cell line databases/resources CLO; CLO_0008816
Encyclopedic resources Wikidata; Q54950470
Entry history
Entry creation04-Apr-2012
Last entry update29-Jun-2023
Version number14