ID   RIN-m
AC   CVCL_3584
SY   RINm
DR   CLO; CLO_0008818
DR   CLDB; cl4151
DR   ATCC; CRL-2057
DR   ECACC; 95071701
DR   Wikidata; Q54950480
RX   PubMed=6106192;
RX   PubMed=6129963;
RX   PubMed=6141566;
RX   PubMed=6295859;
RX   PubMed=8697299;
RX   PubMed=8806089;
RX   PubMed=22538498;
CC   Characteristics: Established from the transplantable insulinoma RIN.
CC   Characteristics: Secretes insulin and somatostatin (PubMed=6106192; PubMed=6141566).
CC   Transformant: NCIt; C17262; X-Ray.
CC   Derived from site: In situ; Pancreas, islets of Langerhans; UBERON=UBERON_0000006.
CC   Cell type: Pancreatic beta cell; CL=CL_0000169.
CC   Breed/subspecies: NEDH.
DI   NCIt; C121566; Rat insulinoma
OX   NCBI_TaxID=10116; ! Rattus norvegicus (Rat)
OI   CVCL_0352 ! INS-1
OI   CVCL_J993 ! INS-2
OI   CVCL_D163 ! RIN-r
SX   Male
AG   666D
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 29-06-23; Version: 14
//
RX   PubMed=6106192; DOI=10.1073/pnas.77.6.3519;
RA   Gazdar A.F., Chick W.L., Oie H.K., Sims H.L., King D.L., Weir G.C.,
RA   Lauris V.;
RT   "Continuous, clonal, insulin- and somatostatin-secreting cell lines
RT   established from a transplantable rat islet cell tumor.";
RL   Proc. Natl. Acad. Sci. U.S.A. 77:3519-3523(1980).
//
RX   PubMed=6129963; DOI=10.1210/endo-112-3-1070;
RA   Oie H.K., Gazdar A.F., Minna J.D., Weir G.C., Baylin S.B.;
RT   "Clonal analysis of insulin and somatostatin secretion and L-dopa
RT   decarboxylase expression by a rat islet cell tumor.";
RL   Endocrinology 112:1070-1075(1983).
//
RX   PubMed=6141566; DOI=10.3181/00379727-175-41762;
RA   Bhathena S.J., Awoke S., Voyles N.R., Wilkins S.D., Recant L.,
RA   Oie H.K., Gazdar A.F.;
RT   "Insulin, glucagon, and somatostatin secretion by cultured rat islet
RT   cell tumor and its clones.";
RL   Proc. Soc. Exp. Biol. Med. 175:35-38(1984).
//
RX   PubMed=6295859; DOI=10.2337/diab.31.6.521;
RA   Bhathena S.J., Oie H.K., Gazdar A.F., Voyles N.R., Wilkins S.D.,
RA   Recant L.;
RT   "Insulin, glucagon, and somatostatin receptors on cultured cells and
RT   clones from rat islet cell tumor.";
RL   Diabetes 31:521-531(1982).
//
RX   PubMed=8697299;
RA   Poitout V., Olson L.K., Robertson R.P.;
RT   "Insulin-secreting cell lines: classification, characteristics and
RT   potential applications.";
RL   Diabetes Metab. 22:7-14(1996).
//
RX   PubMed=8806089; DOI=10.1002/jcb.240630502;
RA   Gazdar A.F., Minna J.D.;
RT   "NCI series of cell lines: an historical perspective.";
RL   J. Cell. Biochem. 63 Suppl. 24:1-11(1996).
//
RX   PubMed=22538498; DOI=10.1159/000338793;
RA   Grozinsky-Glasberg S., Shimon I., Rubinfeld H.;
RT   "The role of cell lines in the study of neuroendocrine tumors.";
RL   Neuroendocrinology 96:173-187(2012).
//