| Cell line name |
I 2.1 |
|---|
| Synonyms |
I-2-1; I2.1; I2-1 |
|---|
| Accession |
CVCL_3724 |
|---|
| Resource Identification Initiative |
To cite this cell line use: I 2.1 (RRID:CVCL_3724) |
|---|
| Comments |
Population: Caucasian.
Transformant: ChEBI; CHEBI:132982; Acridine half-mustard dihydrochloride (6-chloro-9-[3-(2-chloroethylamino)propylamino]-2-methoxyacridine dihydrochloride; Acridine mutagen ICR 191).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084. |
|---|
| Sequence variations |
- Mutation; HGNC; 959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
|
|---|
| Disease |
Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
|---|
| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
|---|
| Hierarchy |
Parent: CVCL_1061 (Jurkat clone A3) |
|---|
| Sex of cell |
Male |
|---|
| Age at sampling |
14Y |
|---|
| Category |
Cancer cell line |
|---|
| STR profile |
Source(s): ATCC; CCRID
Markers:| Amelogenin | X (CCRID)
X,Y (ATCC) |
| CSF1PO | 11,12 |
| D2S1338 | 19,23 |
| D3S1358 | 15,17 |
| D5S818 | 9 |
| D7S820 | 8,10 |
| D8S1179 | 12,14 |
| D13S317 | 8,11 |
| D16S539 | 11 |
| D18S51 | 13,21 |
| D19S433 | 13,15.2 |
| D21S11 | 31.2,33.2 |
| FGA | 19,22 |
| TH01 | 6,9.3 |
| TPOX | 8,10 |
| vWA | 17,18 |
Run an STR similarity search on this cell line |
|---|
| Publications | PubMed=10616904
Juo P., Woo M.S.-A., Kuo C.J., Signorelli P., Biemann H.-P., Hannun Y.A., Blenis J.
FADD is required for multiple signaling events downstream of the receptor Fas.
Cell Growth Differ. 10:797-804(1999) |
|---|
| Cross-references |
|---|
| Cell line collections (Providers) |
ATCC; CRL-2572
|
|---|
| Cell line databases/resources |
CLO; CLO_0004316
cancercelllines; CVCL_3724
CCRID; 1101HUM-PUMC000241
Cell_Model_Passport; SIDM01223
LINCS_LDP; LCL-1027
|
|---|
| Biological sample resources |
BioSample; SAMN03471680
|
|---|
| Encyclopedic resources |
Wikidata; Q54897059
|
|---|
| Entry history |
|---|
| Entry creation | 04-Apr-2012 |
|---|
| Last entry update | 05-Oct-2023 |
|---|
| Version number | 25 |
|---|