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Cellosaurus MCF-12A (CVCL_3744)

[Text version]

Cell line name MCF-12A
Synonyms MCF12A; Michigan Cancer Foundation-12A
Accession CVCL_3744
Resource Identification Initiative To cite this cell line use: MCF-12A (RRID:CVCL_3744)
Comments Part of: ICBP43 breast cancer cell line panel.
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: Glycoproteome analysis by proteomics.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
HLA typing Source: PubMed=25960936
Class I
HLA-AA*66:01,02:01
HLA-BB*41:02,18:01/35:08
HLA-CC*07:01,17:01
Class II
HLA-DRDRB1*11:67,11:67
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_3745 ! MCF-12F
Sex of cell Female
Age at sampling 63Y
Category Spontaneously immortalized cell line
STR profile Source(s): ATCC

Markers:
AmelogeninX
CSF1PO10,11
D5S81811,13
D7S8208,11
D13S3179,11
D16S5399,12
TH017
TPOX8
vWA18

Run an STR similarity search on this cell line
Web pages http://lincs.hms.harvard.edu/resources/reagents/icbp43/
Publications

Patent=US5206165
Pauley R.J., Paine T.J., Soule H.D.
Immortal human mammary epithelial cell sublines.
Patent number US5206165, 27-Apr-1993

PubMed=17157791; DOI=10.1016/j.ccr.2006.10.008
Neve R.M., Chin K., Fridlyand J., Yeh J., Baehner F.L., Fevr T., Clark L., Bayani N., Coppe J.P., Tong F., Speed T., Spellman P.T., DeVries S., Lapuk A., Wang N.J., Kuo W.L., Stilwell J.L., Pinkel D., Albertson D.G., Waldman F.M., McCormick F., Dickson R.B., Johnson M.D., Lippman M.E., Ethier S.P., Gazdar A.F., Gray J.W.
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes.
Cancer Cell 10:515-527(2006)

PubMed=24162158; DOI=10.1007/s10549-013-2743-3
Prat A., Karginova O., Parker J.S., Fan C., He X., Bixby L., Harrell J.C., Roman E., Adamo B., Troester M., Perou C.M.
Characterization of cell lines derived from breast cancers and normal mammary tissues for the study of the intrinsic molecular subtypes.
Breast Cancer Res. Treat. 142:237-255(2013)

PubMed=24176112; DOI=10.1186/gb-2013-14-10-r110
Daemen A., Griffith O.L., Heiser L.M., Wang N.J., Enache O.M., Sanborn Z., Pepin F., Durinck S., Korkola J.E., Griffith M., Hur J.S., Huh N., Chung J., Cope L., Fackler M.J., Umbricht C., Sukumar S., Seth P., Sukhatme V.P., Jakkula L.R., Lu Y., Mills G.B., Cho R.J., Collisson E.A., van't Veer L.J., Spellman P.T., Gray J.W.
Modeling precision treatment of breast cancer.
Genome Biol. 14:R110.1-R110.14(2013)

PubMed=25960936; DOI=10.4161/21624011.2014.954893
Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:E954893-E954893(2014)

PubMed=28287265; DOI=10.1021/acs.jproteome.6b00470
Yen T.-Y., Bowen S., Yen R., Piryatinska A., Macher B.A., Timpe L.C.
Glycoproteins in claudin-low breast cancer cell lines have a unique expression profile.
J. Proteome Res. 16:1391-1400(2017)

Cross-references
Cell line collections ATCC; CRL-10782
Cell line databases/resources LINCS_HMS; 51089
LINCS_LDP; LCL-2082
TOKU-E; 2381
Ontologies BTO; BTO:0002544
CLO; CLO_0007603
EFO; EFO_0001202
Biological sample resources BioSample; SAMN03472816
Chemistry resources ChEMBL-Cells; CHEMBL3307365
ChEMBL-Targets; CHEMBL614322
Gene expression databases GEO; GSM756372
GEO; GSM845396
GEO; GSM844585
GEO; GSM1053717
GEO; GSM1172975
GEO; GSM1172884
GEO; GSM1238117
Other Wikidata; Q54904301
Polymorphism and mutation databases Cosmic; 1017163
Cosmic; 1136378
Cosmic; 1176637
Cosmic; 2560249
Proteomic databases PRIDE; PXD005339