Cellosaurus NK-92MI (CVCL_3755)

Cell line name NK-92MI
Synonyms NK-92 MI; NK-92 mi; NK92-MI; NK92MI; NK-92 transfected with MFG-hIL2
Accession CVCL_3755
Resource Identification Initiative To cite this cell line use: NK-92MI (RRID:CVCL_3755)
Comments Characteristics: No longer dependent on IL2.
Microsatellite instability: Stable (MSS) (Sanger).
Transfected with: HGNC; 6001; IL2.
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Disease Natural killer cell lymphoblastic leukemia/lymphoma (NCIt: C82217)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2142 (NK-92)
Children: CVCL_JX95 (NK-92MIhCD16); CVCL_JX96 (NK-92MIhCD64)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): ATCC; Cosmic-CLP

Markers:
AmelogeninX,Y
CSF1PO11,12
D13S3179,12
D16S53911,12
D5S81812,13
D7S82010,11
TH016,9.3
TPOX8
vWA16,18
Publications

PubMed=10365666; DOI=10.1089/10430349950018030
Tam Y.K., Maki G., Miyagawa B., Hennemann B., Tonn T., Klingemann H.-G.
Characterization of genetically altered, interleukin 2-independent natural killer cell lines suitable for adoptive cellular immunotherapy.
Hum. Gene Ther. 10:1359-1373(1999)

Patent=US8034332
Klingemann H.-G.
Interleukin-secreting natural killer cell lines and methods of use.
Patent number US8034332, 11-Oct-2011

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections ATCC; CRL-2408
ATCC; PTA-6671 - Discontinued
BCRC; 60438
KCB; KCB 200677YJ
Cell line databases/resources CCRID; 3111C0002000000065
CCRID; 3131C0001000200022
Cosmic-CLP; 1330981
GDSC; 1330981
LINCS_LDP; LCL-1127
Ontologies CLO; CLO_0008178
Gene expression databases GEO; GSM1670278