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Cellosaurus PWR-1E (CVCL_3775)

[Text version]

Cell line name PWR-1E
Synonyms PWR1E
Accession CVCL_3775
Resource Identification Initiative To cite this cell line use: PWR-1E (RRID:CVCL_3775)
Comments Group: Patented cell line.
Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-11611.
Population: Caucasian.
Microsatellite instability: Stable (MSS) (Sanger).
Transformant: Ad12-SV40.
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Prostate; epithelial cells.
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0
East Asian, North2.82
East Asian, South0
South Asian0
European, North64.08
European, South30.58
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 67Y
Category Transformed cell line
STR profile Source(s): ATCC; Cosmic-CLP


Run an STR similarity search on this cell line

PubMed=8761420; DOI=10.1093/carcin/17.8.1641
Webber M.M., Bello D., Kleinman H.K., Wartinger D.D., Williams D.E., Rhim J.S.
Prostate specific antigen and androgen receptor induction and characterization of an immortalized adult human prostatic epithelial cell line.
Carcinogenesis 17:1641-1646(1996)

PubMed=8977636; DOI=10.1002/(SICI)1097-0045(199612)29:6<386::AID-PROS7>3.0.CO;2-6
Webber M.M., Bello D., Quader S.T.A.
Immortalized and tumorigenic adult human prostatic epithelial cell lines: characteristics and applications. Part I. Cell markers and immortalized nontumorigenic cell lines.
Prostate 29:386-394(1996)

Webber M.M., Rhim J.S.
Human prostatic cell lines immortalized by adenovirus 12-simian virus 40 (AD12/SV40) hybrid virus.
Patent number US5814452, 29-Sep-1998

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cell line collections ATCC; CRL-11611
Cell line databases/resources CCLE; PWR1E_PROSTATE
Cell_Model_Passport; SIDM01114
Cosmic-CLP; 1330993
DepMap; ACH-001383
Ontologies BTO; BTO:0005178
CLO; CLO_0008671
Biological sample resources BioSample; SAMN03471342
Chemistry resources GDSC; 1330993
PharmacoDB; PWR1E_1279_2019
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM827268
GEO; GSM1670354
Other Wikidata; Q54948720
Polymorphism and mutation databases Progenetix; CVCL_3775
Entry history
Entry creation04-Apr-2012
Last entry update23-Sep-2021
Version number22