ID   RKO-AS45-1
AC   CVCL_3786
SY   RKO-AS-45-1; RKOAS451; RKO_AS45
DR   BTO; BTO:0001892
DR   CLO; CLO_0008826
DR   ATCC; CRL-2579
DR   BioSample; SAMN03471685
DR   cancercelllines; CVCL_3786
DR   CCRID; 3101HUMTCHu117
DR   CLS; 305146
DR   Cosmic; 1187316
DR   GEO; GSM206539
DR   GEO; GSM274767
DR   GEO; GSM274768
DR   Wikidata; Q54950557
RX   PubMed=7973727;
CC   Sequence variation: Mutation; HGNC; 173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11773; TGFBR2; Simple; p.Leu452Pro (c.1355T>C); ClinVar=VCV000930524; Zygosity=Heterozygous (from parent cell line).
CC   Transfected with: HGNC; 4095; GADD45A.
CC   Omics: Transcriptome analysis by microarray.
CC   Misspelling: RKO-AS4; Cosmic=1187316.
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
ST   Source(s): ATCC
ST   Amelogenin: X
ST   CSF1PO: 8,11
ST   D13S317: 8,11
ST   D16S539: 12.1,13
ST   D5S818: 11,13
ST   D7S820: 8,10
ST   TH01: 6,10
ST   TPOX: 10,11
ST   vWA: 16,24
DI   NCIt; C4910; Colon carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0504 ! RKO
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 25
//
RX   PubMed=7973727; DOI=10.1126/science.7973727;
RA   Smith M.L., Chen I.-T., Zhan Q.-M., Bae I., Chen C.-Y., Gilmer T.M.,
RA   Kastan M.B., O'Connor P.M., Fornace A.J. Jr.;
RT   "Interaction of the p53-regulated protein Gadd45 with proliferating
RT   cell nuclear antigen.";
RL   Science 266:1376-1380(1994).
//