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Cellosaurus RKO-E6 (CVCL_3787)

[Text version]

Cell line name RKO-E6
Synonyms RKOE6
Accession CVCL_3787
Resource Identification Initiative To cite this cell line use: RKO-E6 (RRID:CVCL_3787)
Comments Transfected with: UniProtKB; P03126; Human papillomavirus type 16 (HPV16) protein E6.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Sequence variations Heterozygous for ACVR2A p.Lys437fs*19 (c.1309_1310delAA) and p.Lys437fs*5 (c.1310delA) (from parent cell line).
Heterozygous for BRAF p.Val600Glu (c.1799T>A) (from parent cell line).
PIK3CA p.His1047Arg (c.3140A>G) (from parent cell line).
Heterozygous for TGFBR2 p.Lys128Serfs*35 (c.383delA) and p.Leu452Pro (c.1355T>C) (from parent cell line).
Disease Colon carcinoma (NCIt: C4910)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0504 (RKO)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): ATCC; PubMed=25877200

Markers:
AmelogeninX
CSF1PO8,11
D3S135816,19
D5S81812,13
D7S8208,10
D8S11799,13,14
D13S3178,12
D16S53913,13.1
D18S5111,13
D21S1128,30
FGA19,22
Penta D10,11
Penta E11,13
TH016.2,10 (ATCC)
6,10 (PubMed=25877200)
TPOX10,11
vWA16

Run an STR similarity search on this cell line
Web pages http://www.cellresource.cn/fdetail.aspx?id=686
Publications

PubMed=8387205; DOI=10.1073/pnas.90.9.3988
Kessis T.D., Slebos R.J., Nelson W.G., Kastan M.B., Plunkett B.S., Han S.M., Lorincz A.T., Hedrick L., Cho K.R.
Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage.
Proc. Natl. Acad. Sci. U.S.A. 90:3988-3992(1993)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

Cross-references
Cell line collections ATCC; CRL-2578
Cell line databases/resources CCRID; 3131C0001000700118
Cell_Model_Passport; SIDM01253
ColonAtlas; RKOE6
IGRhCellID; RKOE6
Ontologies BTO; BTO:0001891
CLO; CLO_0008827
EFO; EFO_0002318
Biological sample resources BioSample; SAMN03471683
BioSample; SAMN03472970
Chemistry resources PharmacoDB; RKOE6_1317_2019
Gene expression databases ArrayExpress; E-MTAB-2706
Other Wikidata; Q54950558
Polymorphism and mutation databases Cosmic; 1184102
Cosmic; 1187317
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number15