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Cellosaurus RKO-E6 (CVCL_3787)

[Text version]

Cell line name RKO-E6
Synonyms RKOE6
Accession CVCL_3787
Resource Identification Initiative To cite this cell line use: RKO-E6 (RRID:CVCL_3787)
Comments Transfected with: UniProtKB; P03126; Human papillomavirus type 16 (HPV16) protein E6.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Sequence variations Mutation; HGNC; 173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11773; TGFBR2; Simple; p.Leu452Pro (c.1355T>C); ClinVar=VCV000930524; Zygosity=Heterozygous (from parent cell line).
Disease Colon carcinoma (NCIt: C4910)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0504 (RKO)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): ATCC; PubMed=25877200

Markers:
AmelogeninX
CSF1PO8,11
D3S135816,19
D5S81812,13
D7S8208,10
D8S11799,13,14
D13S3178,12
D16S53913,13.1
D18S5111,13
D21S1128,30
FGA19,22
Penta D10,11
Penta E11,13
TH016,10 (PubMed=25877200)
6.2,10 (ATCC)
TPOX10,11
vWA16

Run an STR similarity search on this cell line
Publications

PubMed=8387205; DOI=10.1073/pnas.90.9.3988
Kessis T.D., Slebos R.J., Nelson W.G., Kastan M.B., Plunkett B.S., Han S.M., Lorincz A.T., Hedrick L., Cho K.R.
Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage.
Proc. Natl. Acad. Sci. U.S.A. 90:3988-3992(1993)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

Cross-references
Cell line collections ATCC; CRL-2578
Cell line databases/resources CCRID; 3101HUMTCHu118
Cell_Model_Passport; SIDM01253
ColonAtlas; RKOE6
IGRhCellID; RKOE6
Ontologies BTO; BTO:0001891
CLO; CLO_0008827
EFO; EFO_0002318
Biological sample resources BioSample; SAMN03471683
BioSample; SAMN03472970
Chemistry resources PharmacoDB; RKOE6_1317_2019
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-2706
Other Wikidata; Q54950558
Polymorphism and mutation databases Cosmic; 1184102
Cosmic; 1187317
Progenetix; CVCL_3787
Entry history
Entry creation04-Apr-2012
Last entry update23-Sep-2021
Version number20