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Cellosaurus RWPE-1 (CVCL_3791)

[Text version]

Cell line name RWPE-1
Synonyms RWPE1
Accession CVCL_3791
Resource Identification Initiative To cite this cell line use: RWPE-1 (RRID:CVCL_3791)
Comments Part of: ENCODE project common cell types; tier 3.
Doubling time: ~22 hours (PBCF).
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_4794 (CTPE)CVCL_3792 (RWPE-2)CVCL_K282 (WPE-int)
CVCL_K283 (WPE-stem)CVCL_3810 (WPE1-NA22)CVCL_3811 (WPE1-NB11)
CVCL_3812 (WPE1-NB14)CVCL_3813 (WPE1-NB26)
Originate from same individual CVCL_3814 ! WPMY-1
Sex of cell Male
Age at sampling 54Y
Category Transformed cell line
STR profile Source(s): ATCC; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO13
D3S135815,16
D5S81812,15
D7S82010,11
D8S117910,14
D13S3178,14
D16S5399,11
D18S5114,16
D21S1129,31
FGA24,25
Penta D10,13
Penta E5,12
TH018,9.3
TPOX8,11
vWA14,18

Run an STR similarity search on this cell line
Web pages https://physics.cancer.gov/docs/bioresource/prostate/NCI-PBCF-CRL11609_RWPE-1_SOP-508.pdf
http://genome.ucsc.edu/ENCODE/protocols/cell/human/RWPE_Crawford_protocol.pdf
http://www.cellresource.cn/fdetail.aspx?id=912
http://www.cellresource.cn/fdetail.aspx?id=1659
Publications

PubMed=8977636; DOI=10.1002/(SICI)1097-0045(199612)29:6<386::AID-PROS7>3.0.CO;2-6
Webber M.M., Bello D., Quader S.T.A.
Immortalized and tumorigenic adult human prostatic epithelial cell lines: characteristics and applications. Part I. Cell markers and immortalized nontumorigenic cell lines.
Prostate 29:386-394(1996)

PubMed=9214605; DOI=10.1093/carcin/18.6.1215
Bello D., Webber M.M., Kleinman H.K., Wartinger D.D., Rhim J.S.
Androgen responsive adult human prostatic epithelial cell lines immortalized by human papillomavirus 18.
Carcinogenesis 18:1215-1223(1997)

PubMed=9214606; DOI=10.1093/carcin/18.6.1225
Webber M.M., Bello D., Kleinman H.K., Hoffman M.P.
Acinar differentiation by non-malignant immortalized human prostatic epithelial cells and its loss by malignant cells.
Carcinogenesis 18:1225-1231(1997)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30787054; DOI=10.1158/1055-9965.EPI-18-1132
Hooker S.E., Woods-Burnham L., Bathina M., Lloyd S.M., Gorjala P., Mitra R., Nonn L., Kimbro K.S., Kittles R.
Genetic ancestry analysis reveals misclassification of commonly used cancer cell lines.
Cancer Epidemiol. Biomarkers Prev. 28:1003-1009(2019)

Cross-references
Cell line collections ATCC; CRL-11609
BCRJ; 0389
CCTCC; GDC0178
Cell line databases/resources CCRID; 3131C0001000200037
CCRID; 3142C0001000000144
Cell_Model_Passport; SIDM00020
IGRhCellID; RWPE1
Lonza; 870
Ontologies BTO; BTO:0003709
CLO; CLO_0008905
EFO; EFO_0002323
Biological sample resources BioSample; SAMN03470832
BioSample; SAMN05292437
BioSample; SAMN07709991
BioSample; SAMN07709992
BioSample; SAMN07709993
BioSample; SAMN07709994
BioSample; SAMN07709995
BioSample; SAMN07709996
BioSample; SAMN07709997
ENCODE; ENCBS263AAA
Chemistry resources PharmacoDB; RWPE1_1336_2019
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM827387
GEO; GSM1008595
GEO; GSM1374860
GEO; GSM1670396
Other Wikidata; Q54951497
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number23