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Cellosaurus RWPE-1 (CVCL_3791)

[Text version]

Cell line name RWPE-1
Synonyms RWPE1
Accession CVCL_3791
Resource Identification Initiative To cite this cell line use: RWPE-1 (RRID:CVCL_3791)
Comments Group: Patented cell line.
Part of: ENCODE project common cell types; tier 3.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-11609.
Population: Caucasian.
Doubling time: ~22 hours (PBCF).
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Prostate; epithelium.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_4794 (CTPE )CVCL_3792 (RWPE-2 )CVCL_K282 (WPE-int )
CVCL_K283 (WPE-stem )CVCL_3810 (WPE1-NA22 )CVCL_3811 (WPE1-NB11 )
CVCL_3812 (WPE1-NB14 )CVCL_3813 (WPE1-NB26 )
Originate from same individual CVCL_3814 ! WPMY-1
Sex of cell Male
Age at sampling 54Y
Category Transformed cell line
STR profile Source(s): ATCC; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO13
D3S135815,16
D5S81812,15
D7S82010,11
D8S117910,14
D13S3178,14
D16S5399,11
D18S5114,16
D21S1129,31
FGA24,25
Penta D10,13
Penta E5,12
TH018,9.3
TPOX8,11
vWA14,18

Run an STR similarity search on this cell line
Web pages https://physics.cancer.gov/docs/bioresource/prostate/NCI-PBCF-CRL11609_RWPE-1_SOP-508.pdf
http://genome.ucsc.edu/ENCODE/protocols/cell/human/RWPE_Crawford_protocol.pdf
Publications

PubMed=8977636; DOI=10.1002/(SICI)1097-0045(199612)29:6<386::AID-PROS7>3.0.CO;2-6
Webber M.M., Bello D., Quader S.T.A.
Immortalized and tumorigenic adult human prostatic epithelial cell lines: characteristics and applications. Part I. Cell markers and immortalized nontumorigenic cell lines.
Prostate 29:386-394(1996)

PubMed=9214605; DOI=10.1093/carcin/18.6.1215
Bello D., Webber M.M., Kleinman H.K., Wartinger D.D., Rhim J.S.
Androgen responsive adult human prostatic epithelial cell lines immortalized by human papillomavirus 18.
Carcinogenesis 18:1215-1223(1997)

PubMed=9214606; DOI=10.1093/carcin/18.6.1225
Webber M.M., Bello D., Kleinman H.K., Hoffman M.P.
Acinar differentiation by non-malignant immortalized human prostatic epithelial cells and its loss by malignant cells.
Carcinogenesis 18:1225-1231(1997)

Patent=US6255058
Webber M.M., Rhim J.S.
Immortalized and malignant human prostatic cell lines.
Patent number US6255058, 03-Jul-2001

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22275356; DOI=10.1074/jbc.M111.302547
Lynch T.P., Ferrer C.M., Jackson S.R., Shahriari K.S., Vosseller K., Reginato M.J.
Critical role of O-linked beta-N-acetylglucosamine transferase in prostate cancer invasion, angiogenesis, and metastasis.
J. Biol. Chem. 287:11070-11081(2012)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30787054; DOI=10.1158/1055-9965.EPI-18-1132
Hooker S.E. Jr., Woods-Burnham L., Bathina M., Lloyd S.M., Gorjala P., Mitra R., Nonn L., Kimbro K.S., Kittles R.
Genetic ancestry analysis reveals misclassification of commonly used cancer cell lines.
Cancer Epidemiol. Biomarkers Prev. 28:1003-1009(2019)

Cross-references
Cell line collections ATCC; CRL-11609
BCRJ; 0389
CCTCC; GDC0178
Cell line databases/resources CLO; CLO_0008905
CCRID; 3101HUMGNHu37
CCRID; 3101HUMSCSP5025
CCRID; 4201HUM-CCTCC00178
Cell_Model_Passport; SIDM00020
IGRhCellID; RWPE1
Lonza; 870
Anatomy/cell type resources BTO; BTO:0003709
Biological sample resources BioSample; SAMN03470832
BioSample; SAMN05292437
BioSample; SAMN07709991
BioSample; SAMN07709992
BioSample; SAMN07709993
BioSample; SAMN07709994
BioSample; SAMN07709995
BioSample; SAMN07709996
BioSample; SAMN07709997
ENCODE; ENCBS124FCL
ENCODE; ENCBS192LWI
ENCODE; ENCBS263AAA
ENCODE; ENCBS875FPF
Chemistry resources PharmacoDB; RWPE1_1336_2019
Encyclopedic resources Wikidata; Q54951497
Experimental variables resources EFO; EFO_0002323
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-3610
GEO; GSM827387
GEO; GSM1008595
GEO; GSM1374860
GEO; GSM1670396
Polymorphism and mutation databases Progenetix; CVCL_3791
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update16-Dec-2021
Version number29