ID   RWPE-1
AC   CVCL_3791
SY   RWPE1
DR   BTO; BTO:0003709
DR   CLO; CLO_0008905
DR   EFO; EFO_0002323
DR   ArrayExpress; E-MTAB-38
DR   ArrayExpress; E-MTAB-3610
DR   ATCC; CRL-11609
DR   BCRJ; 0389
DR   BioSample; SAMN03470832
DR   BioSample; SAMN05292437
DR   BioSample; SAMN07709991
DR   BioSample; SAMN07709992
DR   BioSample; SAMN07709993
DR   BioSample; SAMN07709994
DR   BioSample; SAMN07709995
DR   BioSample; SAMN07709996
DR   BioSample; SAMN07709997
DR   CCRID; 3101HUMGNHu37
DR   CCRID; 3101HUMSCSP5025
DR   CCRID; 4201HUM-CCTCC00178
DR   CCTCC; GDC0178
DR   Cell_Model_Passport; SIDM00020
DR   EGA; EGAS00001000978
DR   ENCODE; ENCBS124FCL
DR   ENCODE; ENCBS192LWI
DR   ENCODE; ENCBS263AAA
DR   ENCODE; ENCBS875FPF
DR   GEO; GSM827387
DR   GEO; GSM1008595
DR   GEO; GSM1374860
DR   GEO; GSM1670396
DR   IGRhCellID; RWPE1
DR   Lonza; 870
DR   PharmacoDB; RWPE1_1336_2019
DR   Progenetix; CVCL_3791
DR   Wikidata; Q54951497
RX   Patent=US6255058;
RX   PubMed=8977636;
RX   PubMed=9214605;
RX   PubMed=9214606;
RX   PubMed=20215515;
RX   PubMed=22275356;
RX   PubMed=27397505;
RX   PubMed=30787054;
WW   https://physics.cancer.gov/docs/bioresource/prostate/NCI-PBCF-CRL11609_RWPE-1_SOP-508.pdf
WW   http://genome.ucsc.edu/ENCODE/protocols/cell/human/RWPE_Crawford_protocol.pdf
CC   Group: Patented cell line.
CC   Part of: ENCODE project common cell types; tier 3.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-11609.
CC   Population: Caucasian.
CC   Doubling time: ~22 hours (PBCF).
CC   Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
CC   Omics: Deep RNAseq analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis.
CC   Derived from sampling site: Prostate; epithelium. Cell type=Epithelial cell.
ST   Source(s): ATCC; PubMed=25877200
ST   Amelogenin: X,Y
ST   CSF1PO: 13
ST   D13S317: 8,14
ST   D16S539: 9,11
ST   D18S51: 14,16
ST   D21S11: 29,31
ST   D3S1358: 15,16
ST   D5S818: 12,15
ST   D7S820: 10,11
ST   D8S1179: 10,14
ST   FGA: 24,25
ST   Penta D: 10,13
ST   Penta E: 5,12
ST   TH01: 8,9.3
ST   TPOX: 8,11
ST   vWA: 14,18
OX   NCBI_TaxID=9606; ! Homo sapiens
OI   CVCL_3814 ! WPMY-1
SX   Male
AG   54Y
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 23-06-22; Version: 30
//
RX   Patent=US6255058;
RA   Webber M.M., Rhim J.S.;
RT   "Immortalized and malignant human prostatic cell lines.";
RL   Patent number US6255058, 03-Jul-2001.
//
RX   PubMed=8977636; DOI=10.1002/(SICI)1097-0045(199612)29:6<386::AID-PROS7>3.0.CO;2-6;
RA   Webber M.M., Bello D., Quader S.T.A.;
RT   "Immortalized and tumorigenic adult human prostatic epithelial cell
RT   lines: characteristics and applications. Part I. Cell markers and
RT   immortalized nontumorigenic cell lines.";
RL   Prostate 29:386-394(1996).
//
RX   PubMed=9214605; DOI=10.1093/carcin/18.6.1215;
RA   Bello D., Webber M.M., Kleinman H.K., Wartinger D.D., Rhim J.S.;
RT   "Androgen responsive adult human prostatic epithelial cell lines
RT   immortalized by human papillomavirus 18.";
RL   Carcinogenesis 18:1215-1223(1997).
//
RX   PubMed=9214606; DOI=10.1093/carcin/18.6.1225;
RA   Webber M.M., Bello D., Kleinman H.K., Hoffman M.P.;
RT   "Acinar differentiation by non-malignant immortalized human prostatic
RT   epithelial cells and its loss by malignant cells.";
RL   Carcinogenesis 18:1225-1231(1997).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458;
RA   Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P.,
RA   Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J.,
RA   Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C.,
RA   Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J.,
RA   Haber D.A.;
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=22275356; DOI=10.1074/jbc.M111.302547;
RA   Lynch T.P., Ferrer C.M., Jackson S.R., Shahriari K.S., Vosseller K.,
RA   Reginato M.J.;
RT   "Critical role of O-linked beta-N-acetylglucosamine transferase in
RT   prostate cancer invasion, angiogenesis, and metastasis.";
RL   J. Biol. Chem. 287:11070-11081(2012).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017;
RA   Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P.,
RA   Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H.,
RA   Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H.,
RA   Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X.,
RA   Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S.,
RA   Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P.,
RA   Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H.,
RA   Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.;
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=30787054; DOI=10.1158/1055-9965.EPI-18-1132;
RA   Hooker S.E. Jr., Woods-Burnham L., Bathina M., Lloyd S.M., Gorjala P.,
RA   Mitra R., Nonn L., Kimbro K.S., Kittles R.;
RT   "Genetic ancestry analysis reveals misclassification of commonly used
RT   cancer cell lines.";
RL   Cancer Epidemiol. Biomarkers Prev. 28:1003-1009(2019).
//