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Cellosaurus K562/Adr (CVCL_3827)

Cell line name K562/Adr
Synonyms K562/adr; K-562adr; K562adr; K562/ADM
Accession CVCL_3827
Secondary accession CVCL_2808
Resource Identification Initiative To cite this cell line use: K562/Adr (RRID:CVCL_3827)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
Omics: SNP array analysis.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
STR profile Source(s): JCRB; RCB; TKG


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PubMed=3091555; DOI=10.20772/cancersci1985.77.7_682
Tsuruo T., Iida-Saito H., Kawabata H., Oh-hara T., Hamada H., Utakoji T.
Characteristics of resistance to adriamycin in human myelogenous leukemia K562 resistant to adriamycin and in isolated clones.
Jpn. J. Cancer Res. 77:682-692(1986)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

Cell line collections (Providers) JCRB; JCRB1002
JCRB; NIHS0053 - Discontinued
RCB; RCB1898
TKG; TKG 0211
Cell line databases/resources CLO; CLO_0009840
CLO; CLO_0050121
cancercelllines; CVCL_3827
Anatomy/cell type resources BTO; BTO:0002554
Chemistry resources ChEMBL-Cells; CHEMBL3833721
ChEMBL-Targets; CHEMBL4296449
PubChem_Cell_line; CVCL_3827
Encyclopedic resources Wikidata; Q54899403
Gene expression databases GEO; GSM827221
Polymorphism and mutation databases Progenetix; CVCL_3827
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number26