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Cellosaurus HaCaT II-4 (CVCL_3868)

[Text version]
Cell line name HaCaT II-4
Synonyms HaCaT-ras clone II-4; HaCaT-ras II-4; II-4
Accession CVCL_3868
Resource Identification Initiative To cite this cell line use: HaCaT II-4 (RRID:CVCL_3868)
Comments Population: Caucasian.
Characteristics: Tumorigenic.
Transfected with: HGNC; 5173; HRAS.
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Back, skin, epidermis; UBERON=UBERON_0001068+UBERON_0001003.
Cell type: Keratinocyte; CL=CL_0000312.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.His179Tyr (c.535C>T); ClinVar=VCV000127815; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg282Trp (c.843_844CC>TT); Zygosity=Heterozygous (from parent cell line).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0038 (HaCaT)
Sex of cell Male
Age at sampling 62Y
Category Spontaneously immortalized cell line
STR profile Source(s): CLS

Markers:
AmelogeninX
CSF1PO9,11
D1S165611,12
D2S44111
D2S133817,25
D3S135816
D5S81812
D7S8209,11
D8S117914
D10S124814,15
D12S39118,23
D13S31710,12
D16S5399,12
D18S5112
D19S43313,14
D21S1128,30.2
D22S104515,16
FGA24,27.2
SE3315,18.2
TH019.3
TPOX11,12
vWA16,17

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Publications

PubMed=11583982; DOI=10.1016/S0002-9440(10)62541-2
Mueller M.M., Peter W., Mappes M., Huelsen A., Steinbauer H., Boukamp P., Vaccariello M.A., Garlick J.A., Fusenig N.E.
Tumor progression of skin carcinoma cells in vivo promoted by clonal selection, mutagenesis, and autocrine growth regulation by granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor.
Am. J. Pathol. 159:1567-1579(2001)

PubMed=17056607; DOI=10.1093/carcin/bgl188
Willhauck M.J., Mirancea N., Vosseler S., Pavesio A., Boukamp P., Mueller M.M., Fusenig N.E., Stark H.-J.
Reversion of tumor phenotype in surface transplants of skin SCC cells by scaffold-induced stroma modulation.
Carcinogenesis 28:595-610(2007)

PubMed=20097197; DOI=10.1016/j.yexcr.2010.01.020
Rasanen K., Vaheri A.
Proliferation and motility of HaCaT keratinocyte derivatives is enhanced by fibroblast nemosis.
Exp. Cell Res. 316:1739-1747(2010)

Cross-references
Cell line collections (Providers) CLS; 300495
Anatomy/cell type resources BTO; BTO:0005111
Encyclopedic resources Wikidata; Q54872312
Proteomic databases PRIDE; PXD013113
Entry history
Entry creation04-Apr-2012
Last entry update29-Jun-2023
Version number16