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Cellosaurus HaCaT II-4 (CVCL_3868)

[Text version]

Cell line name HaCaT II-4
Synonyms HaCaT-ras clone II-4; HaCaT-ras II-4; II-4
Accession CVCL_3868
Resource Identification Initiative To cite this cell line use: HaCaT II-4 (RRID:CVCL_3868)
Comments Characteristics: Tumorigenic.
Transfected with: HGNC; 5173; HRAS.
Derived from sampling site: Back; skin; epidermis; keratinocyte.
Sequence variations Heterozygous for TP53 p.His179Tyr (c.535C>T) (ClinVar=VCV000127815) (from parent cell line).
Heterozygous for TP53 p.Arg282Trp (c.843_844CC>TT) (from parent cell line).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0038 (HaCaT)
Sex of cell Male
Age at sampling 62Y
Category Spontaneously immortalized cell line

PubMed=11583982; DOI=10.1016/S0002-9440(10)62541-2
Mueller M.M., Peter W., Mappes M., Huelsen A., Steinbauer H., Boukamp P., Vaccariello M., Garlick J., Fusenig N.E.
Tumor progression of skin carcinoma cells in vivo promoted by clonal selection, mutagenesis, and autocrine growth regulation by granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor.
Am. J. Pathol. 159:1567-1579(2001)

PubMed=17056607; DOI=10.1093/carcin/bgl188
Willhauck M.J., Mirancea N., Vosseler S., Pavesio A., Boukamp P., Mueller M.M., Fusenig N.E., Stark H.-J.
Reversion of tumor phenotype in surface transplants of skin SCC cells by scaffold-induced stroma modulation.
Carcinogenesis 28:595-610(2007)

PubMed=20097197; DOI=10.1016/j.yexcr.2010.01.020
Rasanen K., Vaheri A.
Proliferation and motility of HaCaT keratinocyte derivatives is enhanced by fibroblast nemosis.
Exp. Cell Res. 316:1739-1747(2010)

Cell line collections CLS; 300495/p36437_HaCaT-ras_II-4
Ontologies BTO; BTO:0005111
Other Wikidata; Q54872312
Proteomic databases PRIDE; PXD013113
Entry history
Entry creation04-Apr-2012
Last entry update12-Jan-2021
Version number11