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Cellosaurus LNCaP-CL1 (CVCL_3872)

[Text version]

Cell line name LNCaP-CL1
Synonyms CL1; CL-1
Accession CVCL_3872
Resource Identification Initiative To cite this cell line use: LNCaP-CL1 (RRID:CVCL_3872)
Comments Characteristics: Androgen-independent. Has highly locally invasive and metastatic properties.
Omics: Deep proteome analysis.
Sequence variations Homozygous for AR p.Thr878Ala (c.2632A>G) (from parent cell line).
Heterozygous for MEN1 p.Tyr313Ter (c.939T>A) (from parent cell line).
Heterozygous for PIK3R1 p.Arg639Ter (c.1915C>T) (from parent cell line).
PTEN p.Lys6Argfs*4 (c.17_18delAA) (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Derived from metastatic site: Left supraclavicular lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0395 (LNCaP)
Children:
CVCL_4924 (LNCaP-CL1-GFP)CVCL_RK71 (LNCaP-CL2)
Sex of cell Male
Age at sampling 50Y
Category Cancer cell line
Publications

PubMed=10992426; DOI=10.1016/S0022-5347(05)67210-2
Patel B.J., Pantuck A.J., Zisman A., Tsui K.-H., Paik S.H., Caliliw R., Sheriff S., Wu L., deKernion J.B., Tso C.-L., Belldegrun A.S.
CL1-GFP: an androgen independent metastatic tumor model for prostate cancer.
J. Urol. 164:1420-1425(2000)

PubMed=11038142
Tso C.-L., McBride W.H., Sun J., Patel B., Tsui K.-H., Paik S.H., Gitlitz B., Caliliw R., van Ophoven A., Wu L., deKernion J.B., Belldegrun A.S.
Androgen deprivation induces selective outgrowth of aggressive hormone-refractory prostate cancer clones expressing distinct cellular and molecular properties not present in parental androgen-dependent cancer cells.
Cancer J. Sci. Am. 6:220-233(2000)

PubMed=15162376; DOI=10.1002/pros.20031
Liu A.Y., Brubaker K.D., Goo Y.A., Quinn J.E., Kral S., Sorensen C.M., Vessella R.L., Belldegrun A.S., Hood L.E.
Lineage relationship between LNCaP and LNCaP-derived prostate cancer cell lines.
Prostate 60:98-108(2004)

PubMed=15833837; DOI=10.1158/0008-5472.CAN-04-3218
Lin B., White J.T., Lu W., Xie T., Utleg A.G., Yan X., Yi E.C., Shannon P., Khrebtukova I., Lange P.H., Goodlett D.R., Zhou D., Vasicek T.J., Hood L.E.
Evidence for the presence of disease-perturbed networks in prostate cancer cells by genomic and proteomic analyses: a systems approach to disease.
Cancer Res. 65:3081-3091(2005)

Cross-references
Ontologies BTO; BTO:0005673
Other Wikidata; Q54902832
Entry history
Entry creation04-Apr-2012
Last entry update02-Jul-2020
Version number15