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Cellosaurus SW1222 (CVCL_3886)

[Text version]

Cell line name SW1222
Synonyms SW-1222; SW 1222
Accession CVCL_3886
Resource Identification Initiative To cite this cell line use: SW1222 (RRID:CVCL_3886)
Comments From: Scott and White Clinic; Temple; USA.
Microsatellite instability: Stable (MSS) (PubMed=25926053).
Omics: Deep RNAseq analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Colon.
Sequence variations Mutation; HGNC; 583; APC; Simple; p.Glu1306Ter (c.3916G>T) (E1288*, c.3862G>T); ClinVar=VCV000376059; Zygosity=Unspecified (PubMed=24755471).
Mutation; HGNC; 6407; KRAS; Simple; p.Ala146Val (c.437C>T); ClinVar=VCV000375962; Zygosity=Unspecified (PubMed=20570890).
Mutation; HGNC; 6770; SMAD4; Simple; p.Leu540Arg (c.1619T>G); Zygosity=Unspecified (PubMed=24755471).
Mutation; HGNC; 11998; TP53; Unexplicit; Ex1 113 bp del; Zygosity=Unspecified (PubMed=16418264).
HLA typing Source: PubMed=8464898
Class I
HLA-AA*01
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): ECACC; PubMed=25926053

Markers:
AmelogeninX,Y
CSF1PO11
D5S8189
D7S82010,12
D13S3179 (PubMed=25926053)
9,13 (ECACC)
D16S5399,10
D21S1129
TH017
TPOX10
vWA18

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Publications

PubMed=924690; DOI=10.1002/ijc.2910200505
Kerbel R.S., Pross H.F., Leibovitz A.
Analysis of established human carcinoma cell lines for lymphoreticular-associated membrane receptors.
Int. J. Cancer 20:673-679(1977)

PubMed=286328; DOI=10.1073/pnas.76.3.1438
Herlyn M., Steplewski Z., Herlyn D., Koprowski H.
Colorectal carcinoma-specific antigen: detection by means of monoclonal antibodies.
Proc. Natl. Acad. Sci. U.S.A. 76:1438-1442(1979)

PubMed=6220172
Dracopoli N.C., Fogh J.
Polymorphic enzyme analysis of cultured human tumor cell lines.
J. Natl. Cancer Inst. 70:469-476(1983)

PubMed=6582512; DOI=10.1073/pnas.81.2.568
Mattes M.J., Cordon-Cardo C., Lewis J.L. Jr., Old L.J., Lloyd K.O.
Cell surface antigens of human ovarian and endometrial carcinoma defined by mouse monoclonal antibodies.
Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984)

PubMed=3518877; DOI=10.3109/07357908609038260
Fogh J.
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=1778766; DOI=10.1111/j.1349-7006.1991.tb01816.x
Takeshima E., Hamaguchi M., Watanabe T., Akiyama S., Kataoka M., Ohnishi Y., Xiao H.Y., Nagai Y., Takagi H.
Aberrant elevation of tyrosine-specific phosphorylation in human gastric cancer cells.
Jpn. J. Cancer Res. 82:1428-1435(1991)

PubMed=8464898; DOI=10.1073/pnas.90.7.2842
Browning M.J., Krausa P., Rowan A.J., Bicknell D.C., Bodmer J.G., Bodmer W.F.
Tissue typing the HLA-A locus from genomic DNA by sequence-specific PCR: comparison of HLA genotype and surface expression on colorectal tumor cell lines.
Proc. Natl. Acad. Sci. U.S.A. 90:2842-2845(1993)

PubMed=9294210; DOI=10.1073/pnas.94.19.10330
Ilyas M., Tomlinson I.P.M., Rowan A., Pignatelli M., Bodmer W.F.
Beta-catenin mutations in cell lines established from human colorectal cancers.
Proc. Natl. Acad. Sci. U.S.A. 94:10330-10334(1997)

PubMed=10737795; DOI=10.1073/pnas.97.7.3352
Rowan A.J., Lamlum H., Ilyas M., Wheeler J., Straub J., Papadopoulou A., Bicknell D.C., Bodmer W.F., Tomlinson I.P.M.
APC mutations in sporadic colorectal tumors: a mutational 'hotspot' and interdependence of the 'two hits'.
Proc. Natl. Acad. Sci. U.S.A. 97:3352-3357(2000)

PubMed=16418264; DOI=10.1073/pnas.0510146103
Liu Y., Bodmer W.F.
Analysis of P53 mutations and their expression in 56 colorectal cancer cell lines.
Proc. Natl. Acad. Sci. U.S.A. 103:976-981(2006)

PubMed=20570890; DOI=10.1158/0008-5472.CAN-10-0192
Janakiraman M., Vakiani E., Zeng Z.-S., Pratilas C.A., Taylor B.S., Chitale D., Halilovic E., Wilson M., Huberman K., Ricarte Filho J.C., Persaud Y., Levine D.A., Fagin J.A., Jhanwar S.C., Mariadason J.M., Lash A., Ladanyi M., Saltz L.B., Heguy A., Paty P.B., Solit D.B.
Genomic and biological characterization of exon 4 KRAS mutations in human cancer.
Cancer Res. 70:5901-5911(2010)

PubMed=20606684; DOI=10.1038/sj.bjc.6605780
Bracht K., Nicholls A.M., Liu Y., Bodmer W.F.
5-fluorouracil response in a large panel of colorectal cancer cell lines is associated with mismatch repair deficiency.
Br. J. Cancer 103:340-346(2010)

PubMed=24755471; DOI=10.1158/0008-5472.CAN-14-0013
Mouradov D., Sloggett C., Jorissen R.N., Love C.G., Li S., Burgess A.W., Arango D., Strausberg R.L., Buchanan D., Wormald S., O'Connor L., Wilding J.L., Bicknell D.C., Tomlinson I.P.M., Bodmer W.F., Mariadason J.M., Sieber O.M.
Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer.
Cancer Res. 74:3238-3247(2014)

PubMed=25926053; DOI=10.1038/ncomms8002
Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G., Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S., Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M., Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002-7002(2015)

Cross-references
Cell line collections ECACC; 12022910
Ximbio; 152434
Cell line databases/resources ColonAtlas; SW1222
Ontologies BTO; BTO:0003105
Gene expression databases GEO; GSM1346888
GEO; GSM1374918
GEO; GSM1448088
Other Wikidata; Q54971074
Polymorphism and mutation databases Cosmic; 876714
Cosmic; 948833
Cosmic; 985653
Cosmic; 986017
Cosmic; 995398
Cosmic; 1043827
Cosmic; 1223148
Cosmic; 1312313
Cosmic; 1479605
Cosmic; 1482523
Cosmic; 1524330
Cosmic; 1803950
Cosmic; 2302013
Cosmic; 2760073
Cosmic; 2800578
IARC_TP53; 21761
Entry history
Entry creation04-Apr-2012
Last entry update23-Sep-2021
Version number26