Cellosaurus cell line A818-1 (CVCL_3891)

• Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (PubMed=11169959).
  
• Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Arg (c.34G>C); ClinVar=VCV000012579; Zygosity=Unspecified (PubMed=8426738; PubMed=11169959).
  

PubMed=1764370; DOI=10.1038/bjc.1991.467
Barton C.M., Staddon S.L., Hughes C.M., Hall P.A., O'Sullivan C., Kloppel G., Theis B., Russell R.C.G., Neoptolemos J., Williamson R.C.N., Lane D.P., Lemoine N.R.
Abnormalities of the p53 tumour suppressor gene in human pancreatic cancer.
Br. J. Cancer 64:1076-1082(1991)

PubMed=1906154
Kalthoff H., Roeder C., Humburg I., Thiele H.-G., Greten H., Schmiegel W.H.
Modulation of platelet-derived growth factor A- and B-chain/c-sis mRNA by tumor necrosis factor and other agents in adenocarcinoma cells.
Oncogene 6:1015-1021(1991)

PubMed=8426738
Kalthoff H., Schmiegel W.H., Roeder C., Kasche D., Schmidt A., Lauer G., Thiele H.-G., Honold G., Pantel K., Riethmuller G., Scherer E., Maurer J., Maacke H., Deppert W.
p53 and K-RAS alterations in pancreatic epithelial cell lesions.
Oncogene 8:289-298(1993)

PubMed=8430098; DOI=10.1073/pnas.90.3.863
Schmiegel W.H., Roeder C., Schmielau J., Rodeck U., Kalthoff H.
Tumor necrosis factor alpha induces the expression of transforming growth factor alpha and the epidermal growth factor receptor in human pancreatic cancer cells.
Proc. Natl. Acad. Sci. U.S.A. 90:863-867(1993)

PubMed=10415853; DOI=10.1111/j.1749-6632.1999.tb09512.x
Lehnert L., Trost H., Schmiegel W.H., Roeder C., Kalthoff H.
Hollow-spheres: a new model for analyses of differentiation of pancreatic duct epithelial cells.
Ann. N. Y. Acad. Sci. 880:83-93(1999)

PubMed=11169959; DOI=10.1002/1097-0215(200002)9999:9999<::AID-IJC1049>3.0.CO;2-C
Sirivatanauksorn V., Sirivatanauksorn Y., Gorman P.A., Davidson J.M., Sheer D., Moore P.S., Scarpa A., Edwards P.A.W., Lemoine N.R.
Non-random chromosomal rearrangements in pancreatic cancer cell lines identified by spectral karyotyping.
Int. J. Cancer 91:350-358(2001)