Cellosaurus cell line A818-4 (CVCL_3892)

• Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (PubMed=11787853).
  
• Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Arg (c.34G>C); ClinVar=VCV000012579; Zygosity=Unspecified (PubMed=8426738; PubMed=11787853).
  

PubMed=1764370; DOI=10.1038/bjc.1991.467
Barton C.M., Staddon S.L., Hughes C.M., Hall P.A., O'Sullivan C., Kloppel G., Theis B., Russell R.C.G., Neoptolemos J., Williamson R.C.N., Lane D.P., Lemoine N.R.
Abnormalities of the p53 tumour suppressor gene in human pancreatic cancer.
Br. J. Cancer 64:1076-1082(1991)

PubMed=1906154
Kalthoff H., Roeder C., Humburg I., Thiele H.-G., Greten H., Schmiegel W.H.
Modulation of platelet-derived growth factor A- and B-chain/c-sis mRNA by tumor necrosis factor and other agents in adenocarcinoma cells.
Oncogene 6:1015-1021(1991)

PubMed=8426738
Kalthoff H., Schmiegel W.H., Roeder C., Kasche D., Schmidt A., Lauer G., Thiele H.-G., Honold G., Pantel K., Riethmuller G., Scherer E., Maurer J., Maacke H., Deppert W.
p53 and K-RAS alterations in pancreatic epithelial cell lesions.
Oncogene 8:289-298(1993)

PubMed=8430098; DOI=10.1073/pnas.90.3.863
Schmiegel W.H., Roeder C., Schmielau J., Rodeck U., Kalthoff H.
Tumor necrosis factor alpha induces the expression of transforming growth factor alpha and the epidermal growth factor receptor in human pancreatic cancer cells.
Proc. Natl. Acad. Sci. U.S.A. 90:863-867(1993)

PubMed=9472115; DOI=10.3892/ijo.12.3.717
Muller C., Grosse Bockhorn A.C., Klusmeier S., Kiehl M., Roeder C., Kalthoff H., Koch O.M.
Lovastatin inhibits proliferation of pancreatic cancer cell lines with mutant as well as with wild-type K-ras oncogene but has different effects on protein phosphorylation and induction of apoptosis.
Int. J. Oncol. 12:717-723(1998)

PubMed=10415853; DOI=10.1111/j.1749-6632.1999.tb09512.x
Lehnert L., Trost H., Schmiegel W.H., Roeder C., Kalthoff H.
Hollow-spheres: a new model for analyses of differentiation of pancreatic duct epithelial cells.
Ann. N. Y. Acad. Sci. 880:83-93(1999)

PubMed=11787853; DOI=10.1007/s004280100474
Moore P.S., Sipos B., Orlandini S., Sorio C., Real F.X., Lemoine N.R., Gress T.M., Bassi C., Kloppel G., Kalthoff H., Ungefroren H., Lohr J.-M., Scarpa A.
Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras, p53, p16 and DPC4/Smad4.
Virchows Arch. 439:798-802(2001)

PubMed=12692724; DOI=10.1007/s00428-003-0784-4
Sipos B., Moser S., Kalthoff H., Torok V., Lohr J.-M., Kloppel G.
A comprehensive characterization of pancreatic ductal carcinoma cell lines: towards the establishment of an in vitro research platform.
Virchows Arch. 442:444-452(2003)